2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Tan-931

Tan-931 is a non-competitive and selective inhibitor of aromatase , with an IC50 is 17.2 μM and a Ki of 40 μM for human aromatase, and an IC50 of 162 μM for rat aromatase. Tan-931 reduces plasma estradiol-17β level and weight of ovaries and uterus in PMSG (HY-N12634)-treated female rats. Tan-931 can be used for the research of estrogen-dependent metastatic breast cancer.

For research use only. We do not sell to patients.

Tan-931

Tan-931 Chemical Structure

CAS No. : 127448-92-4

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Tan-931 Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Description

Tan-931 is a non-competitive and selective inhibitor of aromatase , with an IC50 is 17.2 μM and a Ki of 40 μM for human aromatase, and an IC50 of 162 μM for rat aromatase. Tan-931 reduces plasma estradiol-17β level and weight of ovaries and uterus in PMSG (HY-N12634)-treated female rats. Tan-931 can be used for the research of estrogen-dependent metastatic breast cancer[1][2].

IC50 & Target[1][2]

Aromatase

17.2 μM (IC50)

Aromatase

40 μM (Ki)

Cellular Effect
Cell Line Type Value Description References
MDCK IC50
58.6 μM
Compound: 7, TAN-931
Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as compound concentration required for inhibiting influenza virus yield at 48 h post-infection by crystal violet staining based CPE inhibition assay
Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as compound concentration required for inhibiting influenza virus yield at 48 h post-infection by crystal violet staining based CPE inhibition assay
[PMID: 21879714]
In Vitro

Tan-931 weakly inhibits aromatase in a microsomal assay with an IC50 of 17.2 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tan-931 Related Antibodies
In Vivo

Tan-931 (25-100 mg/kg; s.c.; daily for 4 days) reduces plasma estradiol 17β level and weight of ovaries and uterus in PMSG-treated female rats[1].
Tan-931 (100 mg/kg; s.c., twice daily for 7 days) dose not induce adrenal hypertrophy in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague-Dawley (20-day-old) challenged with PMSG[1]
Dosage: 25, 50, 100 mg/kg
Administration: s.c.; daily for 4 days
Result: Reduced PMSG-induced increases in plasma estradiol-17β level and ovarian weight in a dose-dependent manner.
Reduced plasma estradiol-17β.
Slightly reduced uterine weight.
Reduced total and specific ovarian aromatase activity.
Animal Model: Sprague-Dawley (9-week-old male)[1]
Dosage: 100 mg/kg
Administration: s.c., twice daily for 7 days
Result: Did not induce adrenal hypertrophy.
Caused a significant increase in body weight.
Did not affect liver weight relative to controls.
Molecular Weight

302.24

Formula

C15H10O7
CAS No.
SMILES

O=CC1=CC(C(O)=O)=CC(O)=C1C(C2=C(O)C=CC=C2O)=O
Structure Classification
Initial Source

Penicillium funiculosum
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tan-931 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tan-931127448-92-4Tan931Tan 931Cytochrome P450CYPsgonadotropin-treated female ratsovariesestrogen-dependent metastatic breast canceruterusplasma estradiol 17βaromataseandrostenedionemale ratsSprague-Dawley ratsadrenal hypertrophyInhibitorinhibitorinhibit

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