Tan-931
Tan-931 is a non-competitive and selective inhibitor of aromatase , with an IC50 is 17.2 μM and a Ki of 40 μM for human aromatase, and an IC50 of 162 μM for rat aromatase. Tan-931 reduces plasma estradiol-17β level and weight of ovaries and uterus in PMSG (HY-N12634)-treated female rats. Tan-931 can be used for the research of estrogen-dependent metastatic breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 127448-92-4
- Formula: C15H10O7
- Molecular Weight:302.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Aromatase 17.2 μM (IC50) |
Aromatase 40 μM (Ki) |
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Cell Line
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Type | Value | Description | References |
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| MDCK | IC50 |
58.6 μM
Compound: 7, TAN-931
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Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as compound concentration required for inhibiting influenza virus yield at 48 h post-infection by crystal violet staining based CPE inhibition assay
Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as compound concentration required for inhibiting influenza virus yield at 48 h post-infection by crystal violet staining based CPE inhibition assay
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[PMID: 21879714] |
Tan-931 weakly inhibits aromatase in a microsomal assay with an IC50 of 17.2 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Tan-931 (100 mg/kg; s.c., twice daily for 7 days) dose not induce adrenal hypertrophy in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Sprague-Dawley (20-day-old) challenged with PMSG[1]
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Dosage:25, 50, 100 mg/kg
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Administration:s.c.; daily for 4 days
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Result:Reduced PMSG-induced increases in plasma estradiol-17β level and ovarian weight in a dose-dependent manner.
Reduced plasma estradiol-17β.
Slightly reduced uterine weight.
Reduced total and specific ovarian aromatase activity.
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Animal Model:Sprague-Dawley (9-week-old male)[1]
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Dosage:100 mg/kg
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Administration:s.c., twice daily for 7 days
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Result:Did not induce adrenal hypertrophy.
Caused a significant increase in body weight.
Did not affect liver weight relative to controls.
Chemical Information
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CAS No. 127448-92-4
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Molecular Weight 302.24
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Formula C15H10O7
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SMILES
O=CC1=CC(C(O)=O)=CC(O)=C1C(C2=C(O)C=CC=C2O)=O
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Structure Classification
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Initial Source
Penicillium funiculosum
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ishii T, et al. TAN-931, a novel nonsteroidal aromatase inhibitor produced by Penicillium funiculosum No. 8974. I. Taxonomy, fermentation, isolation,characterization and biological activities. J Antibiot (Tokyo). 1991 Jun;44(6):589-99. [Content Brief]
[2]. Balunas MJ, et al. Natural products as aromatase inhibitors. Anticancer Agents Med Chem. 2008 Aug;8(6):646-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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