127448-92-4
Chemical Structure
Tan-931
- CAS No.: 127448-92-4
- Formula:C15H10O7
- Molecular Weight:302.24
IUPAC Name: 4-(2,6-dihydroxybenzoyl)-3-formyl-5-hydroxybenzoic acid
InChIKey: INVAPAXTQZQLGN-UHFFFAOYSA-N
SMILES: O=CC1=CC(C(O)=O)=CC(O)=C1C(C2=C(O)C=CC=C2O)=O
Biological Activity: Tan-931 is a non-competitive and selective inhibitor of aromatase , with an IC50 is 17.2 μM and a Ki of 40 μM for human aromatase, and an IC50 of 162 μM for rat aromatase. Tan-931 reduces plasma estradiol-17β level and weight of ovaries and uterus in PMSG (HY-N12634)-treated female rats. Tan-931 can be used for the research of estrogen-dependent metastatic breast cancer[1][2].
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Tan-931 | Tan-931 is a non-competitive and selective inhibitor of aromatase , with an IC50 is 17.2 μM and a Ki of 40 μM for human aromatase, and an IC50 of 162 μM for rat aromatase. Tan-931 reduces plasma estradiol-17β level and weight of ovaries and uterus in PMSG (HY-N12634)-treated female rats. Tan-931 can be used for the research of estrogen-dependent metastatic breast cancer. | |||||||||||||||||||||
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- [1]. Ishii T, et al. TAN-931, a novel nonsteroidal aromatase inhibitor produced by Penicillium funiculosum No. 8974. I. Taxonomy, fermentation, isolation,characterization and biological activities. J Antibiot (Tokyo). 1991 Jun;44(6):589-99. [Content Brief]
- [2]. Balunas MJ, et al. Natural products as aromatase inhibitors. Anticancer Agents Med Chem. 2008 Aug;8(6):646-82. [Content Brief]
Keywords
