trans-Cinnamaldehyde

Name: trans-Cinnamaldehyde
Brand: MedChemExpress
SKU: HY-W019711
Rating: 5.0 (7 reviews)

Cat. No.: HY-W019711 Purity: 99.07%: Data Sheet
COA

SDS
Handling Instructions
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trans-Cinnamaldehyde can be used to prepare highly polyfunctionalized furan ring by reaction of alkyl isocyanides with dialkyl acetylenedicarboxylate. trans-Cinnamaldehyde can be used to synthesize trans-cinnamaldehyde -β-cyclodextrin complex, an antimicrobial edible coating that increases the shelf life of fresh-cut fruits.

For research use only. We do not sell to patients.

CAS No. : 14371-10-9

Size	Stock	Quantity
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	Get quote
50 g	Get quote

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Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of trans-Cinnamaldehyde:

trans-Cinnamaldehyde (Standard) In-stock

7 Publications Citing Use of MCE trans-Cinnamaldehyde

•Dis Markers. 2022 Jan 19:2022:6530934.

In Vivo Efficacy Study

ELISA

: trans-Cinnamaldehyde purchased from MedChemExpress. Usage Cited in: Biomolecules. 2025 Feb 1;15(2):208.; TRPA1 agonist cinnamaldehyde (CA, 5 mg/kg). In citric acid-induced enhanced cough guinea pigs, there was a significant increase in cough frequency. However, the cough frequency in the guinea pigs with a cough was not further increased by the activation of PAR2/TRPA1. Inhibition of PAR2 or TRPA1 significantly reduced the cough frequency in guinea pigs with a cough.

: trans-Cinnamaldehyde purchased from MedChemExpress. Usage Cited in: Biomolecules. 2025 Feb 1;15(2):208.; TRPA1 agonist cinnamaldehyde (CA, 5 mg/kg). SP levels in the BALF of guinea pigs with a cough were further increased by the activation of PAR2. Inhibition of PAR2/TRPA1 decreased the level of SP in the BALF of guinea pigs with a cough.

: trans-Cinnamaldehyde purchased from MedChemExpress. Usage Cited in: Biomolecules. 2025 Feb 1;15(2):208.; TRPA1 agonist cinnamaldehyde (CA, 5 mg/kg). The changes in CGRP levels in the BALF of guinea pigs.

: trans-Cinnamaldehyde purchased from MedChemExpress. Usage Cited in: Biomolecules. 2025 Feb 1;15(2):208.; TRPA1 agonist cinnamaldehyde (CA, 5 mg/kg). The expression of TRPA1 in the nerve fibers of the trachea was increased in the citric acid-induced enhanced cough group after drug treatment. Activation of PAR2 upregulated TRPA1 expression, whereas inhibition of PAR2 in cough group suppressed TRPA1 expression.

: trans-Cinnamaldehyde purchased from MedChemExpress. Usage Cited in: Biomolecules. 2025 Feb 1;15(2):208.; TRPA1 agonist cinnamaldehyde (CA, 5 mg/kg). The expression of PAR2 in the nerve fibers of the trachea was increased in the cough group after drug treatment, whereas TRPA1 receptor activation/inhibition had no effect on PAR2 expression.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

trans-Cinnamaldehyde can be used to prepare highly polyfunctionalized furan ring by reaction of alkyl isocyanides with dialkyl acetylenedicarboxylate^[1]. trans-Cinnamaldehyde can be used to synthesize trans-cinnamaldehyde -β-cyclodextrin complex, an antimicrobial edible coating that increases the shelf life of fresh-cut fruits^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	6.5 μM Compound: 15	Activation of TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels Activation of TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels	[PMID: 20356305]
CHO	EC₅₀	61 μM Compound: CA	Agonist activity at mouse TRPA1 expressed in CHO cells assessed as increase in calcium influx by Fluo-3 based FLIPR analysis Agonist activity at mouse TRPA1 expressed in CHO cells assessed as increase in calcium influx by Fluo-3 based FLIPR analysis	[PMID: 30878828]
HCT-8	IC₅₀	15.6 μM Compound: 12; CA	Antiproliferative activity against human HCT8 cells after 72 hrs in presence of aspirin by MTT assay Antiproliferative activity against human HCT8 cells after 72 hrs in presence of aspirin by MTT assay	[PMID: 30037494]
HCT-8	IC₅₀	29.4 μM Compound: 12; CA	Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT8 cells after 72 hrs by MTT assay	[PMID: 30037494]
HEK293	EC₅₀	51.4 μM Compound: CA 3	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as [45]Ca2+ influx by microbeta plate count Agonist activity at human TRPA1 expressed in HEK293 cells assessed as [45]Ca2+ influx by microbeta plate count	[PMID: 19945872]
HEK293	EC₅₀	9 μM Compound: CA	Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay	[PMID: 30878828]
RAW264.7	IC₅₀	43 μM Compound: CA	Inhibition of NF-kappaB transfected in LPS-stimulated mouse RAW264.7 cells Inhibition of NF-kappaB transfected in LPS-stimulated mouse RAW264.7 cells	[PMID: 18823786]

In Vitro

trans-cinnamaldehyde -β-cyclodextrin complex against Salmonella spp. and Lis-teria spp. with minimum inhibitory concentrations ranging from 10 to 20 mg/mL, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

132.16

Formula

C₉H₈O

CAS No.

14371-10-9

Appearance

Liquid (Density: 1.05 g/cm³)

Color

Colorless to light yellow

SMILES

O=C/C=C/C1=CC=CC=C1

Structure Classification

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (378.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.5666 mL	37.8329 mL	75.6659 mL
5 mM	1.5133 mL	7.5666 mL	15.1332 mL
10 mM	0.7567 mL	3.7833 mL	7.5666 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (18.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (18.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (18.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.41%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (245 KB) HNMR (114 KB) GC (103 KB)

Handling Instructions (2659 KB)

References

[1]. Asghari S, et al. A Facile One-Pot Synthesis of Amino Furans Using Trans-Cinnamaldehyde in the Presence of Nucleophilic Isocyanides. Acta Chimica Slovenica 54(3), 341-350, (2007)

[2]. Brasil IM, et al.Polysaccharide-based multilayered antimicrobial edible coating enhances quality of fresh-cut papaya.LWT--Food Science and Technology 47(1), 39-45, (2012)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.5666 mL	37.8329 mL	75.6659 mL	189.1646 mL
	5 mM	1.5133 mL	7.5666 mL	15.1332 mL	37.8329 mL
	10 mM	0.7567 mL	3.7833 mL	7.5666 mL	18.9165 mL
	15 mM	0.5044 mL	2.5222 mL	5.0444 mL	12.6110 mL
	20 mM	0.3783 mL	1.8916 mL	3.7833 mL	9.4582 mL
	25 mM	0.3027 mL	1.5133 mL	3.0266 mL	7.5666 mL
	30 mM	0.2522 mL	1.2611 mL	2.5222 mL	6.3055 mL
	40 mM	0.1892 mL	0.9458 mL	1.8916 mL	4.7291 mL
	50 mM	0.1513 mL	0.7567 mL	1.5133 mL	3.7833 mL
	60 mM	0.1261 mL	0.6305 mL	1.2611 mL	3.1527 mL
	80 mM	0.0946 mL	0.4729 mL	0.9458 mL	2.3646 mL
	100 mM	0.0757 mL	0.3783 mL	0.7567 mL	1.8916 mL