CCNH - cyclin H Gene

Also Known as CAK; p34; p37; CycH

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 902

About CCNH

Cytogenetic location: 5q14.3 Genomic coordinates (GRCh38): 5:87,311,471-87,412,930 (from NCBI)

This gene has 13 transcripts (splice variants), 216 orthologues and 6 paralogues. Ubiquitous expression in placenta (RPKM 15.0), testis (RPKM 11.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Nov 2010]

CCNH Products (5)

mRNA	Protein	Name
NM_001199189.2	NP_001186118.1	cyclin-H isoform 2
NM_001239.4	NP_001230.1	cyclin-H isoform 1
NM_001363539.2	NP_001350468.1	cyclin-H isoform 3
NM_001364075.2	NP_001351004.1	cyclin-H isoform 4
NM_001364076.2	NP_001351005.1	cyclin-H isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to RNA polymerase II general transcription initiation factor activity	IDA IDA: Inferred from direct assay	7533895	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8521818	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	23393140	GOA
involved in regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	23622515	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9852112	GOA
involved in transcription initiation at RNA polymerase II promoter	IDA IDA: Inferred from direct assay	7533895	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CAK-ERCC2 complex	IDA IDA: Inferred from direct assay	8692841	GOA
part of cyclin-dependent protein kinase holoenzyme complex	IDA IDA: Inferred from direct assay	23622515	GOA
part of transcription factor TFIIH core complex	IDA IDA: Inferred from direct assay	8692841	GOA
part of transcription factor TFIIH holo complex	IDA IDA: Inferred from direct assay	9852112	GOA
part of transcription factor TFIIK complex	IDA IDA: Inferred from direct assay	8692841	GOA
part of transcription factor TFIIK complex	IMP IMP: Inferred from mutant phenotype	23393140	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNH Protein Structure

Cyclin_N

0
100
200
300
323 a.a.

Protein Preferred Names	Protein Names
cyclin-H	CAK complex subunit

CCNH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCNH	P51946	MTMR7	Homo sapiens	Q9Y216	Validated Y2H	32296183
Intra	CCNH	P51946	TRIML2	Homo sapiens	Q8N7C3	Validated Y2H	32296183
Intra	CCNH	P51946	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	CCNH	P51946	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	CCNH	P51946	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	CCNH	P51946	RHOH	Homo sapiens	Q15669	Validated Y2H	32296183
Intra	CCNH	P51946	RHOH	Homo sapiens	Q15669	Y2H Array	32296183
Intra	CCNH	P51946	RHOH	Homo sapiens	Q15669	Y2H Prey Pooling	32296183
Intra	CCNH	P51946	CDK3	Homo sapiens	Q00526	Validated Y2H	32296183
Intra	CCNH	P51946	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	CCNH	P51946	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	CCNH	P51946	KLC3	Homo sapiens	Q6P597	Y2H Prey Pooling	25416956
Intra	CCNH	P51946	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	CCNH	P51946	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	CCNH	P51946	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
Intra	CCNH	P51946	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	CCNH	P51946	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	CCNH	P51946	CCDC170	Homo sapiens	Q8IYT3	Validated Y2H	25416956
Intra	CCNH	P51946	CCDC170	Homo sapiens	Q8IYT3	Y2H Array	25416956
Intra	CCNH	P51946	CDK6	Homo sapiens	Q00534	Validated Y2H	32296183
Intra	CCNH	P51946	SNAPIN	Homo sapiens	O95295	Y2H Prey Pooling	32296183
Intra	CCNH	P51946	SNAPIN	Homo sapiens	O95295	Y2H Array	32296183
Intra	CCNH	P51946	MCRS1	Homo sapiens	Q96EZ8	Y2H Array	32296183
Intra	CCNH	P51946	MCRS1	Homo sapiens	Q96EZ8	Y2H Prey Pooling	32296183
Intra	CCNH	P51946	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	CCNH	P51946	CCT4	Homo sapiens	P50991	Y2H Prey Pooling	32296183
Intra	CCNH	P51946	CCT4	Homo sapiens	P50991	Y2H Array	32296183
Intra	CCNH	P51946	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	CCNH	P51946	PSMA1	Homo sapiens	P25786	Y2H Array	25416956
Intra	CCNH	P51946	PSMA1	Homo sapiens	P25786	Y2H Pooling	16189514
Intra	CCNH	P51946	RARA	Homo sapiens	P10276	Pull Down	16769902
Intra	CCNH	P51946	RARA	Homo sapiens	P10276	Anti Tag CoIP	16769902
Intra	CCNH	P51946	SFN	Homo sapiens	P31947	Y2H Prey Pooling	25416956
Intra	CCNH	P51946	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	CCNH	P51946	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	CCNH	P51946	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	CCNH	P51946	GOLGA2	Homo sapiens	Q08379	Y2H	21988832
Intra	CCNH	P51946	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	CCNH	P51946	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	CCNH	P51946	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	CCNH	P51946	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	CCNH	P51946	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	CCNH	P51946	DUSP12	Homo sapiens	Q9UNI6	Y2H Array	32296183
Intra	CCNH	P51946	DUSP12	Homo sapiens	Q9UNI6	Validated Y2H	25416956
Intra	CCNH	P51946	DUSP12	Homo sapiens	Q9UNI6	Validated Y2H	32296183
Intra	CCNH	P51946	DUSP12	Homo sapiens	Q9UNI6	Y2H Prey Pooling	25416956
Intra	CCNH	P51946	DUSP12	Homo sapiens	Q9UNI6	Y2H Prey Pooling	32296183
Intra	CCNH	P51946	GRIPAP1	Homo sapiens	Q4V328	Validated Y2H	32296183
Intra	CCNH	P51946	GRIPAP1	Homo sapiens	Q4V328	Y2H Array	32296183
Intra	CCNH	P51946	GRIPAP1	Homo sapiens	Q4V328	Y2H Prey Pooling	32296183
Intra	CCNH	P51946	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	CCNH	P51946	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	CCNH	P51946	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	CCNH	P51946	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	CCNH	P51946	ZNRD2	Homo sapiens	O60232	Y2H Pooling	16189514
Intra	CCNH	P51946	ZNRD2	Homo sapiens	O60232	Y2H Prey Pooling	25416956
Intra	CCNH	P51946	CTBP2	Homo sapiens	P56545	Anti Tag CoIP	21988832
Intra	CCNH	P51946	CTBP2	Homo sapiens	P56545	Y2H	21988832
Intra	CCNH	P51946	CTBP2	Homo sapiens	P56545	Y2H Array	21988832
Intra	CCNH	P51946	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	CCNH	P51946	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	CCNH	P51946	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	CCNH	P51946	PPFIA1	Homo sapiens	Q13136	Validated Y2H	25416956
Intra	CCNH	P51946	PPFIA1	Homo sapiens	Q13136	Y2H Array	25416956
Intra	CCNH	P51946	PPFIA1	Homo sapiens	Q13136	Y2H Array	29892012
Intra	CCNH	P51946	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	CCNH	P51946	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	CCNH	P51946	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCNH Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75361	CDK7-CCNH-MNAT1 Protein, Human (Active, sf9, His)	P50613 (A2-F346)&P51946 (Y2-L323)&P51948 (D2-S309)	≥ 85%, as determined by reducing SDS-PAGE.

CCNH Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80636	Cyclin H Antibody (YA788)	WB	Human, Mouse
HY-P80636A	Cyclin H Antibody (YA788)(PBS only)	WB	Human, Mouse
HY-P80637	Cyclin H Antibody (YA482)	WB, IHC-P, ICC/IF, IP, FC, IF-Tissue	Human, Mouse
HY-P85424	Cyclin H Antibody (YA5116)	WB	Human, Mouse, Rat, Dog, Pig
HY-P85532	Cyclin H Antibody (YA5224)	WB, IP	Human
HY-P85532A	Cyclin H Antibody (YA5224)(PBS only)	WB, IP	Human

Related Diseases

Diseases	Alias
Basal Cell Carcinoma, Multiple	Multiple Basal Cell Carcinoma
Angioosteohypertrophic Syndrome	Klippel-Trenaunay-Weber Syndrome Haemangiectatic Hypertrophy
Capillary Malformation-Arteriovenous Malformation 1	Parkes Weber Syndrome Capillary Malformation-Arteriovenous Malformation Capillary Malformation-Arteriovenous Malformation Syndrome CMAVM1 Cmavm Cm-Avm Syndrome Pkws Cm-Avm Parkes-Weber Syndrome Capillary Malformation-Arteriovenous Malformation, Type 1
Basal Cell Carcinoma 1	Basal Cell Carcinoma, Susceptibility To, 1 Basal Cell Carcinoma BCC1 BCC Multiple Basal Cell Carcinoma Non-Syndromic Basal Cell Carcinoma Carcinoma, Basal Cell, Susceptibility To, Type 1 Experimental Organism Basal Cell Carcinoma Basal Cell Carcinoma, Multiple
Telangiectasia, Hereditary Hemorrhagic, Type 1	Orw Disease HHT1 Hht Telangiectasia, Hereditary Hemorrhagic, Of Rendu, Osler, And Weber Osler-Rendu-Weber Disease Telangiectasia, Hereditary Hemorrhagic, 1 Hereditary Hemorrhagic Telangiectasia Of Rendu, Osler, And Weber Orw1 Osler-Rendu-Weber Syndrome Osler-Rendu-Weber Syndrome 1 Telangiectasia Hemorrhagic, Hereditary, Type 1 Hereditary Hemorrhagic Telangiectasia
Hemangioma, Capillary Infantile	HCI Capillary Infantile Hemangioma Hemangioma, Hereditary Capillary Hemangioma, Capillary Infantile, Susceptibility To Hemangioma, Capillary Infantile, Somatic Hemangioma Hereditary Capillary
Hereditary Hemorrhagic Telangiectasia	Rendu-Osler-Weber Disease Hht Osler-Weber-Rendu Disease Telangiectasia, Hereditary Hemorrhagic Osler Hemorrhagic Telangiectasia Syndrome Orw Disease Osler Weber Rendu Syndrome Osler-Rendu-Weber Disease Osler-Weber-Rendu Syndrome Rendu-Osler Disease Telangiectasia Hereditary Hemorrhagic Telangiectasia Hemorrhagic, Hereditary Hht - [Hereditary Haemorrhagic Telangiectasia] Osler Haemorrhagic Telangiectasia Syndrome
Klippel-Trenaunay-Weber Syndrome	Klippel-Trenaunay Syndrome KTS Ktw Syndrome Angioosteohypertrophy Syndrome Angio-Osteohypertrophy Syndrome Klippel Trenaunay Syndrome Klippel-Trénaunay-Weber Syndrome Haemangiectatic Hypertrophy Weber-Klippel-Trenaunay Congenital Dysplastic Angiopathy Klippel-Trenaunay Disease Weber Klippel Trenaunay
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Xeroderma Pigmentosum, Complementation Group B	Xeroderma Pigmentosum Group B Xeroderma Pigmentosum, Group B XPB Xpbc Xp Group B Xp, Group B Xeroderma Pigmentosum Complementation Group B XP-B Xeroderma Pigmentosum Group B With Cockayne Syndrome Xeroderma Pigmentosum Ii Xp2 Xp-B/Cs
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Xeroderma Pigmentosum, Complementation Group D	Xeroderma Pigmentosum, Group D Xpdc Xeroderma Pigmentosum Iv XPD Xeroderma Pigmentosum Group D Xeroderma Pigmentosum Viii Xp Group D Xp Group H Xp4 Xp8 Xph Xp, Group D Xp4 Xeroderma Pigmentosum Viii, Formerly Xp8, Formerly Xp, Group H, Formerly Xph, Formerly Xeroderma Pigmentosum Complementation Group D XP-D Xp-D/Cs
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Xeroderma Pigmentosum, Complementation Group G	Xeroderma Pigmentosum, Group G Xeroderma Pigmentosum Vii Xp7 XPG Xeroderma Pigmentosum Group G Xp Group G Xp, Group G Xpgc Xeroderma Pigmentosum, Group G/Cockayne Syndrome Xeroderma Pigmentosum, Type 7 Xeroderma Pigmentosum Complementation Group G XP-G Xp-G/Cs Xeroderma Pigmentosum Group G/Cockayne Syndrome
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations	Star Syndrome Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome Syndactyly With Renal And Anogenital Malformations STAR Syndactyly, Telecanthus, Anogenital And Renal Malformations Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02132	CCNH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19581	Ccnh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26078	Ccnh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CCNH	VGNC	VGNC:60561
Mus musculus	CCNH	MGD	MGI:1913921
Canis familiaris	CCNH	VGNC	VGNC:38902
Macaca mulatta	CCNH	VGNC	VGNC:70732
Rattus norvegicus	CCNH	RGD	RGD:69419
Bos taurus	CCNH	VGNC	VGNC:97249
Others	CCNH	NCBI