Cyclin H Antibody (YA5116)

Cat. No.: HY-P85424: Data Sheet User Guide for Antibodies
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Cyclin H Antibody (YA5116) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Cyclin H.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Cyclin H Antibody (YA5116) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Cyclin H.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 38 kDa;

Species Reactivity

Human, Mouse, Rat, Dog, Pig

SwissProt ID

P51946

Gene ID

902 [NCBI]

Immunogen

Purified recombinant human Cyclin H protein fragments expressed in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:2000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified

Appearance

Liquid

Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle

Subcellular Localization：Nucleus

Subunit：Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor

Synonyms

CCNH; Cyclin-H; MO15-associated protein; p34; p37

Documentation

User Guide for Antibodies (1077 KB)