Cyclin H Antibody (YA5116)
(Synonyms: CCNH; Cyclin-H; MO15-associated protein; p34; p37)Cyclin H Antibody (YA5116) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Cyclin H.
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Host:
Mouse
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Application:
WB
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Reactivity :
Human, Mouse, Rat, Dog, Pig
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000-1:2000 |
Product Details
Cyclin H Antibody (YA5116) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Cyclin H.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat, Dog, Pig
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Calculated Molecular Weight Predicted band size: 38 kDa;
Purified recombinant human Cyclin H protein fragments expressed in E.coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Cyclin H regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle
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Subcellular Localization
Nucleus
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Subunit
Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor
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SwissProt ID
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Synonyms
CCNH; Cyclin-H; MO15-associated protein; p34; p37
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