L-674573
Based on 1 Customer Validation
L-674573 is a quinoline leukotriene synthesis inhibitor, inhibiting Calcimycin (HY-N6687)- and N-Formyl-Met-Leu-Phe (HY-P0224)-induced leukotriene production with IC50s of 100 nM and 50 nM, respectively. L-674573 selectively inhibits Calcimycin- and N-Formyl-Met-Leu-Phe-induced 5-lipoxygenase translocation.
For research use only. We do not sell to patients.
- Purity: 99.54%
- CAS No.: 127481-29-2
- Formula: C28H27NO3S
- Molecular Weight:457.58
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Leukotriene Receptor Isoforms
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Biological Activity
L-674573 (1 μM) inhibits the Calcimycin (A23187)-induced translocation of 5-lipoxygenase to membranes in HL-60 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 127481-29-2
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Appearance Solid
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Molecular Weight 457.58
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Formula C28H27NO3S
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Color White to off-white
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SMILES
O=C(CSC(CCCC1=CC=CC=C1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 125 mg/mL (273.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1854 mL | 10.9271 mL | 21.8541 mL | 54.6353 mL |
| 5 mM | 0.4371 mL | 2.1854 mL | 4.3708 mL | 10.9271 mL | |
| 10 mM | 0.2185 mL | 1.0927 mL | 2.1854 mL | 5.4635 mL | |
| 15 mM | 0.1457 mL | 0.7285 mL | 1.4569 mL | 3.6424 mL | |
| 20 mM | 0.1093 mL | 0.5464 mL | 1.0927 mL | 2.7318 mL | |
| 25 mM | 0.0874 mL | 0.4371 mL | 0.8742 mL | 2.1854 mL | |
| 30 mM | 0.0728 mL | 0.3642 mL | 0.7285 mL | 1.8212 mL | |
| 40 mM | 0.0546 mL | 0.2732 mL | 0.5464 mL | 1.3659 mL | |
| 50 mM | 0.0437 mL | 0.2185 mL | 0.4371 mL | 1.0927 mL | |
| 60 mM | 0.0364 mL | 0.1821 mL | 0.3642 mL | 0.9106 mL | |
| 80 mM | 0.0273 mL | 0.1366 mL | 0.2732 mL | 0.6829 mL | |
| 100 mM | 0.0219 mL | 0.1093 mL | 0.2185 mL | 0.5464 mL |
L-674573 Related Classifications
HY-120571 Related Classifications
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