1. Cell Cycle/DNA Damage
  2. Deubiquitinase
  3. USP8-IN-1

USP8-IN-1 

Cat. No.: HY-147032 Purity: 99.61%
Handling Instructions

USP8-IN-1 is a USP8 inhibitor with an IC50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI50 of 82.04 μM (CN111138358A; U10).

For research use only. We do not sell to patients.

USP8-IN-1 Chemical Structure

USP8-IN-1 Chemical Structure

CAS No. : 2477650-96-5

Size Price Stock Quantity
5 mg USD 260 In-stock
Estimated Time of Arrival: December 31
10 mg USD 380 In-stock
Estimated Time of Arrival: December 31
25 mg USD 800 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1280 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

USP8-IN-1 is a USP8 inhibitor with an IC50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI50 of 82.04 μM (CN111138358A; U10)[1].

IC50 & Target

IC50: 1.9 μM (USP8)[1]

Molecular Weight

387.46

Formula

C18H21N5O3S

CAS No.
SMILES

[O-][N+](C1=CC=C(NC(N2CCN(CC2)C3=CC=C(C=C3N)OC)=S)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (322.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5809 mL 12.9046 mL 25.8091 mL
5 mM 0.5162 mL 2.5809 mL 5.1618 mL
10 mM 0.2581 mL 1.2905 mL 2.5809 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.37 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
USP8-IN-1
Cat. No.:
HY-147032
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