1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
    Apoptosis
  2. HSP
    Apoptosis
  3. YK5

YK5 

Cat. No.: HY-120909
Handling Instructions

YK5 is a potent and selective Hsp70 inhibitor. YK5 selectively and tightly binds to the cytosolic Hsp70s in cancer cells. YK5 has biological activity partly by interfering with the formation of active oncogenic Hsp70/Hsp90/client protein complexes.

For research use only. We do not sell to patients.

YK5 Chemical Structure

YK5 Chemical Structure

CAS No. : 1268273-23-9

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Description

YK5 is a potent and selective Hsp70 inhibitor. YK5 selectively and tightly binds to the cytosolic Hsp70s in cancer cells. YK5 has biological activity partly by interfering with the formation of active oncogenic Hsp70/Hsp90/client protein complexes[1].

IC50 & Target

HSP70

 

HSP90

 

In Vitro

YK5 shows selectively and tightly binds to the cytosolic Hsp70s[1].
YK5 (0.5, 1, 5 µM; 72 h) degrades the expression of Hsp90/Hsp70-onco-client proteins and also leads to the inhibition of cell proliferation in SKBr3 cells[1].
YK5 (0.5, 1, 5 µM; 24 h) induces the degradation of HER2, Raf-1, Akt kinases, and also induces apoptosis in SKBr3 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SKBr3 cells
Concentration: 0.5, 1, 5 µM
Incubation Time: 72 h
Result: Degraded the expression of Hsp90/Hsp70-onco-client proteins and also led to the inhibition of cell proliferation in SKBr3 cells.

Western Blot Analysis[1]

Cell Line: SKBr3 cells
Concentration: 0.5, 1, 5 µM
Incubation Time: 24 h
Result: Induced the degradation of HER2, Raf-1, Akt kinases, and also induced apoptosis in SKBr3 cells.
Molecular Weight

432.50

Formula

C18H24N8O3S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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YK5
Cat. No.:
HY-120909
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