2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Apoptosis Reactive Oxygen Species (ROS)
  4. α-Tocopherol phosphate disodium

α-Tocopherol phosphate disodium  (Synonyms: alpha-Tocopherol phosphate disodium; TocP disodium; Vitamin E phosphate disodium)

Art. -Nr.: HY-W127530 Reinheit: 98.01%
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α-Tocopherol phosphate disodium is an antioxidant that protects against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium exhibits angiogenesis-promoting activity.

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α-Tocopherol phosphate disodium

α-Tocopherol phosphate disodium Chemische Struktur

CAS. Nr. : 60934-46-5

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Based on 8 publication(s) in Google Scholar

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α-Tocopherol phosphate disodium Related Antibodies

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Beschreibung

α-Tocopherol phosphate disodium is an antioxidant that protects against long-wave UVA1 induced cell death and scavenge UVA1 induced ROS in a skin cell model. α-Tocopherol phosphate disodium exhibits angiogenesis-promoting activity[1][2].

In Vitro

α-Tocopherol phosphate disodium (100 μM, 24 h) inhibits high Glucose (HY-B0389)/ischemic-induced apoptosis and migration in endothelial progenitor cells, promotes capillary-like tube formation through regulation of Bcl-2, Akt, NF-κB, p38MAPK and JNK expressions[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Tocopherol phosphate disodium Related Antibodies

Western Blot Analysis[2]

Cell Line: Endothelial progenitor cells derived from rat bone marrow
Concentration: 100 μM
Incubation Time: 24 h
Result: Upregulated the expression of Bcl-2 and Akt.
Downregulated the expression of Tie2, Notch1, p38MAPK and JNK.

Cell Migration Assay [2]

Cell Line: Endothelial progenitor cells derived from rat bone marrow
Concentration: 100 μM
Incubation Time: 24 h
Result: Promoted the cell migration.
In Vivo

α-Tocopherol phosphate disodium (100 μM, intramuscular, single dose) exhibits angiogenesis-promoting activity in Streptozotocin (HY-13753) and ligation induced rats type 2 diabetes and ischemia models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats type 2 diabetes and ischemia models[2]
Dosage: 100 μM α-Tocopherol phosphate disodium incubated with EPCs
Administration: 24 incubation, intramuscular injection of EPC into rats hind limbs
Result: Increased the capillary density of the ischemic hindlimbs.
Klinische Studie
Molekulargewicht

554.65

Formel

C29H49Na2O5P
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C2C(CC[C@](C)(O2)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C(OP(O[Na])(O[Na])=O)=C1C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 4 mg/mL (7.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8029 mL 9.0147 mL 18.0294 mL
5 mM 0.3606 mL 1.8029 mL 3.6059 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8029 mL 9.0147 mL 18.0294 mL 45.0735 mL
5 mM 0.3606 mL 1.8029 mL 3.6059 mL 9.0147 mL
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α-Tocopherol phosphate disodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Tocopherol phosphate disodium60934-46-5alpha-Tocopherol phosphate disodium TocP disodium Vitamin E phosphate disodiumApoptosisReactive Oxygen Species (ROS)photoprotectiveantioxidantendothelial progenitor cellsHaCaTkeratinocytesUVAangiogenesisInhibitorinhibitorinhibit

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