11β,13-Dihydrolactucin

Cat. No.: HY-N9987 Purity: 99.20%: Data Sheet
COA

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Handling Instructions
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11β,13-Dihydrolactucin is an antimicrobial agent. 11β,13-Dihydrolactucin also has several biological properties, including antioxidant, anti-inflammatory, and antitumor activities.

For research use only. We do not sell to patients.

11β,13-Dihydrolactucin Chemical Structure

CAS No. : 83117-63-9

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Description

11β,13-Dihydrolactucin is an antimicrobial agent. 11β,13-Dihydrolactucin also has several biological properties, including antioxidant, anti-inflammatory, and antitumor activities^[1].

Molecular Weight

278.30

Formula

C₁₅H₁₈O₅

CAS No.

83117-63-9

Appearance

Solid

Color

White to off-white

SMILES

OCC([C@]1([H])[C@]2([H])[C@]([C@H](CC(C)=C13)O)([H])[C@@H](C(O2)=O)C)=CC3=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

Ethanol : 50 mg/mL (179.66 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5932 mL	17.9662 mL	35.9324 mL
5 mM	0.7186 mL	3.5932 mL	7.1865 mL
10 mM	0.3593 mL	1.7966 mL	3.5932 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.20%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (260 KB) HNMR (273 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Weng H, et al. Low Oral Bioavailability and Partial Gut Microbiotic and Phase II Metabolism of Brussels/Witloof Chicory Sesquiterpene Lactones in Healthy Humans. Nutrients. 2020 Nov 28;12(12):3675. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	3.5932 mL	17.9662 mL	35.9324 mL	89.8311 mL
	5 mM	0.7186 mL	3.5932 mL	7.1865 mL	17.9662 mL
	10 mM	0.3593 mL	1.7966 mL	3.5932 mL	8.9831 mL
	15 mM	0.2395 mL	1.1977 mL	2.3955 mL	5.9887 mL
	20 mM	0.1797 mL	0.8983 mL	1.7966 mL	4.4916 mL
	25 mM	0.1437 mL	0.7186 mL	1.4373 mL	3.5932 mL
	30 mM	0.1198 mL	0.5989 mL	1.1977 mL	2.9944 mL
	40 mM	0.0898 mL	0.4492 mL	0.8983 mL	2.2458 mL
	50 mM	0.0719 mL	0.3593 mL	0.7186 mL	1.7966 mL
	60 mM	0.0599 mL	0.2994 mL	0.5989 mL	1.4972 mL
	80 mM	0.0449 mL	0.2246 mL	0.4492 mL	1.1229 mL
	100 mM	0.0359 mL	0.1797 mL	0.3593 mL	0.8983 mL