1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. 8-Hydroxy-DPAT hydrobromide

8-Hydroxy-DPAT hydrobromide (Synonyms: 8-OH-DPAT hydrobromide)

Cat. No.: HY-15688
Handling Instructions

8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site.

For research use only. We do not sell to patients.

8-Hydroxy-DPAT hydrobromide Chemical Structure

8-Hydroxy-DPAT hydrobromide Chemical Structure

CAS No. : 76135-31-4

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Description

8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site[1].

IC50 & Target[1]

5-HT1A Receptor

8.19 (pIC50)

In Vitro

8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) has no effect on 5-HT1B binding at concentrations lower than 100 nM[1].

In Vivo

8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide; 32, 56, 80, 100 mg/kg; intramuscularly; 15 min prior to the testing session) of the highest dose significantly interferes with sustained attention and reinforcer efficacy (progressive ratio; PR) performance in the 3,4-methylenedioxymethamphetamine (MDMA)-exposed but not control animals[1].

Molecular Weight

328.29

Formula

C₁₆H₂₆BrNO

CAS No.

76135-31-4

SMILES

[H]Br.CCCN(CCC)C(CCC1=CC=C2)CC1=C2O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

8-Hydroxy-DPAT8-OH-DPAT5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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8-Hydroxy-DPAT hydrobromide
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HY-15688
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