Adenosine deaminase, microorganism
Based on 1 publication(s) in Google Scholar
Adenosine deaminase (RnADA) (EC 3.5.4.4) is an enzyme that catalyzes the irreversible deamination of adenosine and 2'-deoxyadenosine to inosine and 2'-deoxyinosine, respectively.
For research use only. We do not sell to patients.
- CAS No.: 9026-93-1
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Adenosine deaminase, microorganism
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Biological Activity
Adenosine deaminase (RnADA) catalyzes the irreversible deamination of adenosine and 2′-deoxyadenosine to inosine and 2′-deoxyinosine, respectively. Adenosine deaminase (RnADA) is implicated in purine metabolism and distributed in most mammalian tissues. Genetic Adenosine deaminase deficiency results in lymphopenia and severe combined immunodeficiency disease by decreasing the differentiation and maturation of lymphoid cells[1]. Adenosine deaminase (RnADA) is a signaling molecule related to the activation of T lympho-cytes, making it a useful inflammation marker, especially for menin-gitis and tuberculous pleuritis[2].
This product is derived fro M microbial recombinant protein, is stable at pH 7.0-9.0, and has a molecular weight of 42 kDa (SDS-PAGE).
Solution preparation
Reconstitute with pure water containing 20% glycerol, aliquot according to dosage and freeze at 20°C. It can be stored for 2 years. Try to avoid repeated freezing and thawing.pH7 0 9.0 means the product is stable.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
3.5.4.4
≥5 U/mg soild
150-200 U/mg protein
One unit is defined as the amount of enzyme required to convert 1 μmol of adenosine to inosine per minute at 25°C, pH 7.4
Chemical Information
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CAS No. 9026-93-1
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Appearance Solid
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Color White to off-white
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SMILES
[Adenosine deaminase, microorganism]
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Synonyms
RnADA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Circulation
2024 Apr 23;149(17):1354-1371. PMID: 38314588
Purity & Documentation
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Data Sheet (266 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Tian X, et al. Probing inhibition mechanisms of adenosine deaminase by using molecular dynamics simulations. PLoS One. 2018 Nov 16;13(11):e0207234. [Content Brief]
[2]. Silva Dalsasso Joaquim L, et al. Analytical validation of an in-house method for adenosine deaminase determination. J Clin Lab Anal. 2018 Nov 29:e22823. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)