1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. CXD101

CXD101 

Cat. No.: HY-100748 Purity: 99.14%
Handling Instructions

CXD101 is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively. CXD101 has no activity against HDAC class II. CXD101 has antitumor activity.

For research use only. We do not sell to patients.

CXD101 Chemical Structure

CXD101 Chemical Structure

CAS No. : 934828-12-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 151 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 151 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 70 In-stock
Estimated Time of Arrival: December 31
5 mg USD 170 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 760 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1070 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CXD101 is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively. CXD101 has no activity against HDAC class II. CXD101 has antitumor activity[1][2].

IC50 & Target[1]

HDAC1

63 nM (IC50)

HDAC3

550 nM (IC50)

HDAC2

570 nM (IC50)

In Vitro

CXD101 has been tested in vitro in colon, lung, non-Hodgkin lymphoma, and myeloma cell lines with IC50s ranged from 0.2 to 15 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CXD101 substantially reduces tumor size in murine xenograft lung (A549a) and colon (HT29) models at a dose of 50 mg/kg. Tumor reductions are found to be associated with increased histone acetylation and decreased HDAC enzyme activity[2].
For CXD101, after oral dosing in murine and canine models, peak plasma concentrations (Cmax) are reached 1 to 2 hours after the dose and terminal half‐lives are 6 hours and 8 hours, respectively. After murine oral [14C]-CXD101 at a dose of 1.6 mg/kg (4 μmol/kg), tissue radioactivity peaked 3 to 6 hours after the dose and declined slowly thereafter with CXD101‐related material still present in tissue 21 days after the dose[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

403.52

Formula

C₂₄H₂₉N₅O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (76.82 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4782 mL 12.3910 mL 24.7819 mL
5 mM 0.4956 mL 2.4782 mL 4.9564 mL
10 mM 0.2478 mL 1.2391 mL 2.4782 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.20 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.20 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.20 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
CXD101
Cat. No.:
HY-100748
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