3064994-08-4
3064994-08-4
Chemical Structure
JAK/HDAC-IN-4
- CAS No.: 3064994-08-4
- Formula:C30H32N8O5S
- Molecular Weight:616.69
InChIKey: DBOSQKGNJZTGTC-UHFFFAOYSA-N
SMILES: O=S(NC1=CC=C(C=C1)C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)CC(NC5=CC=C(C=C5)C(NO)=O)=O)=NC=C2)(C)=O
Biological Activity: JAK/HDAC-IN-4 (compound 11 i) is a JAK/HDAC inhibitor with the IC50 values of 0.49 nM and 12 nM for JAK2 and HDAC6, respectively. JAK/HDAC-IN-4 inhibits the cell proliferation and the production of nitric oxide. JAK/HDAC-IN-4 ameliorates psoriasis-like skin lesions in an Imiquimod (HY-B0180)-induced murine model with low toxicity[1].
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JAK/HDAC-IN-4 | JAK/HDAC-IN-4 (compound 11 i) is a JAK/HDAC inhibitor with the IC50 values of 0.49 nM and 12 nM for JAK2 and HDAC6, respectively. JAK/HDAC-IN-4 inhibits the cell proliferation and the production of nitric oxide. JAK/HDAC-IN-4 ameliorates psoriasis-like skin lesions in an Imiquimod (HY-B0180)-induced murine model with low toxicity. | |||||||||||||||||||||
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References
Keywords
