1. GPCR/G Protein
  2. Leukotriene Receptor

MK-571 sodium salt (Synonyms: L-660711 sodium salt)

Cat. No.: HY-19989A Purity: 99.24%
Data Sheet SDS Handling Instructions

MK571 sodium salt is a specific CysLT1 (Cysteinyl-Leukotriene Type 1 Receptor) antagonist.

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MK-571 sodium salt Chemical Structure

MK-571 sodium salt Chemical Structure

CAS No. : 115103-85-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO $59 In-stock
5 mg $50 In-stock
10 mg $80 In-stock
25 mg $180 In-stock
50 mg $320 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

MK571 sodium salt is a specific CysLT1 (Cysteinyl-Leukotriene Type 1 Receptor) antagonist. Target: CysLT1 in vitro: MK571 is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor and has been widely used to demonstrate the role of Mrp2 in the cellular efflux of drugs, xenobiotics and their conjugates. The estimated Ki for inhibition of the synthesis of K-4′-O-GlcA by MK571 is 19.7 μM. MK571 dose-dependently inhibits the intracellular biosynthesis of all flavonol glucuronides and sulphates by Caco-2 cells. MK571 significantly inhibits phase-2 conjugation of kaempferol by cell-free extracts of Caco-2, and production of kaempferol-4′-O-glucuronide was competitively inhibited. These data show that MK571, in addition to inhibiting MRP2, is a potential inhibitor of enterocyte phase-2 conjugation.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.8620 mL 9.3098 mL 18.6195 mL
5 mM 0.3724 mL 1.8620 mL 3.7239 mL
10 mM 0.1862 mL 0.9310 mL 1.8620 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

537.07

Formula

C₂₆H₂₆ClN₂NaO₃S₂

CAS No.

115103-85-0

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 33 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
MK-571 sodium salt
Cat. No.:
HY-19989A
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