1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Prulifloxacin

Prulifloxacin (Synonyms: NM441)

Cat. No.: HY-B0024 Purity: 98.46%
Handling Instructions

Prulifloxacin (NM441) is an orally active fluoroquinolone antibiotic with a broad spectrum of activity against Gram-positive and -negative bacteria. Prulifloxacin is a prodrug of a thiazeto-quinoline carboxylic acid derivative Ulifloxacin (NM394). Prulifloxacin has the potential for lower urinary tract infections and exacerbations of chronic bronchitis.

For research use only. We do not sell to patients.

Prulifloxacin Chemical Structure

Prulifloxacin Chemical Structure

CAS No. : 123447-62-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 112 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 112 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 102 In-stock
Estimated Time of Arrival: December 31
500 mg USD 306 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Prulifloxacin:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Prulifloxacin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Prulifloxacin (NM441) is an orally active fluoroquinolone antibiotic with a broad spectrum of activity against Gram-positive and -negative bacteria. Prulifloxacin is a prodrug of a thiazeto-quinoline carboxylic acid derivative Ulifloxacin (NM394). Prulifloxacin has the potential for lower urinary tract infections and exacerbations of chronic bronchitis[1][2].

In Vivo

After oral administration of NM441 at a dose of 20 mg/kg to dogs, the peak concentration of NM394 in plasma was 2.39 micrograms/ml, whereas it was 0.63 micrograms/ml for NM394 administered alone. NM441 was as effective as ofloxacin and was twice as effective as ciprofloxacin against systemic infection with Staphylococcus aureus. Against infections with streptococci, NM441 was two to three times as effective as ofloxacin and five times as effective as ciprofloxacin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

461.46

Formula

C₂₁H₂₀FN₃O₆S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (27.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1670 mL 10.8352 mL 21.6704 mL
5 mM 0.4334 mL 2.1670 mL 4.3341 mL
10 mM 0.2167 mL 1.0835 mL 2.1670 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (2.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (2.71 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.46%

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Product Name:
Prulifloxacin
Cat. No.:
HY-B0024
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