Others

SAMHD1 ligand-1 is a SAMHD1 ligand that can be used for the synthesis of PROTAC SAMHD1 Degrader-1 (HY-182970).

Pomalidomide-C3-O-C4-O-C3-NH2 is an E3 ligase ligand-linker conjugate that contains Pomalidomide (HY-10984). Pomalidomide-C3-O-C4-O-C3-NH2 can be used for the synthesis of PROTACs targeting glycogen synthase kinase 3β (GSK-3β), such as PROTAC GSK-3β Degrader-1 (HY-149845).

Mannose-PEG1000-Biotin is a conjugate composed of mannose, PEG chains, and biotin. Mannose-PEG-Biotin combines the targeting recognition ability of mannose with the high affinity of biotin to bind avidin/link avidin, and is used for applications such as constructing targeted drug delivery systems and nanoparticle modification.

Mannose-PEG2000-Biotin is a conjugate composed of mannose, PEG chains, and biotin. Mannose-PEG-Biotin combines the targeting recognition ability of mannose with the high affinity of biotin to bind avidin/link avidin, and is used for applications such as constructing targeted drug delivery systems and nanoparticle modification.

Mannose-PEG3400-Biotin is a conjugate composed of mannose, PEG chains, and biotin. Mannose-PEG-Biotin combines the targeting recognition ability of mannose with the high affinity of biotin to bind avidin/link avidin, and is used for applications such as constructing targeted drug delivery systems and nanoparticle modification.

Mannose-PEG5000-Biotin is a conjugate composed of mannose, PEG chains, and biotin. Mannose-PEG-Biotin combines the targeting recognition ability of mannose with the high affinity of biotin to bind avidin/link avidin, and is used for applications such as constructing targeted drug delivery systems and nanoparticle modification.

Mannose-PEG10000-Biotin is a conjugate composed of mannose, PEG chains, and biotin. Mannose-PEG-Biotin combines the targeting recognition ability of mannose with the high affinity of biotin to bind avidin/link avidin, and is used for applications such as constructing targeted drug delivery systems and nanoparticle modification.

DDB1 ligand-1 is a DNA damage-binding protein 1 (DDB1) ligand. DDB1 ligand-1 binds to a unique pocket on the β propeller C (BPC) domain of DDB1, induces conformational changes, and blocks the canonical DCAF/HBx peptide binding site of DDB1. DDB1 ligand-1 engages full-length DDB1 in cellular settings and supports PROTAC development research.

(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is a cyclin-dependent kinase inhibitor.

Mannose-PEG1000-COOH is a conjugate composed of mannose, PEG chains, and carboxyl groups (COOH). Mannose-PEG-COOH combines the targeting recognition ability of mannose with the carboxyl group, which can undergo condensation or esterification reactions with amino and hydroxyl groups, for applications such as targeted drug delivery systems and nanoparticle modification.

Mannose-PEG2000-COOH is a conjugate composed of mannose, PEG chains, and carboxyl groups (COOH). Mannose-PEG-COOH combines the targeting recognition ability of mannose with the carboxyl group, which can undergo condensation or esterification reactions with amino and hydroxyl groups, for applications such as targeted drug delivery systems and nanoparticle modification.

Mannose-PEG3400-COOH is a conjugate composed of mannose, PEG chains, and carboxyl groups (COOH). Mannose-PEG-COOH combines the targeting recognition ability of mannose with the carboxyl group, which can undergo condensation or esterification reactions with amino and hydroxyl groups, for applications such as targeted drug delivery systems and nanoparticle modification.

Mannose-PEG5000-COOH is a conjugate composed of mannose, PEG chains, and carboxyl groups (COOH). Mannose-PEG-COOH combines the targeting recognition ability of mannose with the carboxyl group, which can undergo condensation or esterification reactions with amino and hydroxyl groups, for applications such as targeted drug delivery systems and nanoparticle modification.

Mannose-PEG10000-COOH is a conjugate composed of mannose, PEG chains, and carboxyl groups (COOH). Mannose-PEG-COOH combines the targeting recognition ability of mannose with the carboxyl group, which can undergo condensation or esterification reactions with amino and hydroxyl groups, for applications such as targeted drug delivery systems and nanoparticle modification.

JNK1 ligand-1 is a JNK1 ligand that can be used for the synthesis of PROTACs, such as PROTAC JNK1 degrader-1 (HY-182796).

CRBN ligand-901 (5d in Scheme 2) is a ligand for Cereblon (CRBN). CRBN ligand-901 can be linked to target protein ligands (e.g., VP1 ligand-1) via a linker to form PROTAC molecules (e.g., Jun15702 (HY-182924)).

VP1 ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that can be used for the synthesis of PROTACs, such as Jun15702 (HY-182924).

Mannose-PEG1000-NH2 is composed of mannose, PEG chains, and terminal amino groups (–NH2). Mannose-PEG-NH2 combines the targeting recognition ability of mannose with the chemical modifiability of amino groups, making it suitable for applications such as targeted drug delivery systems and nanoparticle modification.

Mannose-PEG2000-NH2 is composed of mannose, PEG chains, and terminal amino groups (–NH2). Mannose-PEG-NH2 combines the targeting recognition ability of mannose with the chemical modifiability of amino groups, making it suitable for applications such as targeted drug delivery systems and nanoparticle modification.

Mannose-PEG3400-NH2 is composed of mannose, PEG chains, and terminal amino groups (–NH2). Mannose-PEG-NH2 combines the targeting recognition ability of mannose with the chemical modifiability of amino groups, making it suitable for applications such as targeted drug delivery systems and nanoparticle modification.