DDB1 ligand-1
DDB1 ligand-1 is a DNA damage-binding protein 1 (DDB1) ligand. DDB1 ligand-1 binds to a unique pocket on the β propeller C (BPC) domain of DDB1, induces conformational changes, and blocks the canonical DCAF/HBx peptide binding site of DDB1. DDB1 ligand-1 engages full-length DDB1 in cellular settings and supports PROTAC development research.
For research use only. We do not sell to patients.
- Formula: C32H32F2N4O5
- Molecular Weight:590.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cereblon-DDB1 |
DDB1 ligand-1 (Compound 26) binds recombinant His-DDB1ΔB with high potency, as measured by TR-FRET displacement, with an EC50 of 40 nM[1].
DDB1 ligand-1 (0.1-100 μM) engages full-length DDB1 in AD293 cells stably expressing DDB1-HiBiT, stabilizing the protein with an EC50 of 3.55 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 590.62
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Formula C32H32F2N4O5
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SMILES
CNC([C@H]1C[C@H](CN(C1)C(C2=CC(OC(C)C)=C(C3=C2N(C=N3)C)C4=C5OC(F)(OC5=CC=C4)F)=O)C6=CC=CC=C6)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DDB1 ligand-1 Related Classifications
HY-182983 Related Classifications
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