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Art. -Nr.: HY-182983

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DDB1 ligand-1

DDB1 ligand-1 is a DNA damage-binding protein 1 (DDB1) ligand. DDB1 ligand-1 binds to a unique pocket on the β propeller C (BPC) domain of DDB1, induces conformational changes, and blocks the canonical DCAF/HBx peptide binding site of DDB1. DDB1 ligand-1 engages full-length DDB1 in cellular settings and supports PROTAC development research.

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Formel: C₃₂H₃₂F₂N₄O₅
Molecular Weight:590.62

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

DDB1 ligand-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Cereblon-DDB1

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen :

In Vitro

DDB1 ligand-1 (Compound 26) binds recombinant His-DDB1ΔB with high potency, as measured by TR-FRET displacement, with an EC₅₀ of 40 nM^[1].
DDB1 ligand-1 (0.1-100 μM) engages full-length DDB1 in AD293 cells stably expressing DDB1-HiBiT, stabilizing the protein with an EC₅₀ of 3.55 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 590.62
Formel C₃₂H₃₂F₂N₄O₅
SMILES

CNC([C@H]1C[C@H](CN(C1)C(C2=CC(OC(C)C)=C(C3=C2N(C=N3)C)C4=C5OC(F)(OC5=CC=C4)F)=O)C6=CC=CC=C6)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Reddy Guduru SK, et al. DNA-Encoded Library (DEL) Selection Identifies a Distinct DDB1 Ligand Binding Site. ACS Med Chem Lett. 2026;17(4):757-767. Published 2026 Mar 27. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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DDB1 ligand-1

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen