Others

ADP-β-D-ribofuranose is a nucleotide derivative composed of ADP and a ribose unit. ADP-β-D-ribofuranose can be produced by NAD⁺ catalysis.

6-ECDCA-d₄ (6α-ethyl Cheodeoxycholic Acid-d₄, Obeticholic Acid-d₄) is deuterium labeled 6-ECDCA.

N-Desmethyl diltiazem-d₄ is deuterium labeled N-Desmethyl diltiazem.

8(R)-HPETE acts as an intermediate in the conversion of Arachidonic acid to pre-clavulone in Clavularia viridis.

FL2-14 is a CRBN-dependent, selective GSPT2 molecular glue degrader. FL2-14 downregulates GSPT2, FAM83F, and ZBTB39.

5β-Cholanic acid-3,6-dione (3,6-Diketo-LCA) is a similar substance to Lithocholic acid (LCA) (HY-B0172). 5β-Cholanic acid-3,6-dione cannot activate the Vitamin D receptor (VDR), and can be used as a negative control for studying the relationship between LCA derivatives and VDR.

Anti-hFc1 aptamer sodium is an RNA aptamer that targets the Fc fragment of human IgG1 (hFc1).

3'-O-(2-Nitrobenzyl)-dATP is a reversible and photolabile DNA synthesis terminator. 3'-O-(2-Nitrobenzyl)-dATP incorporates into growing DNA strands to terminate synthesis in a base-specific manner. 3'-O-(2-Nitrobenzyl)-dATP undergoes efficient photolytic removal of its 3'-protecting group upon UV exposure to enable reinitiation of DNA synthesis. 3'-O-(2-Nitrobenzyl)-dATP supports development of the Base Addition Sequencing Scheme (BASS) via a complete stop-start DNA synthesis cycle.

PL53 is a kind of cycloalkylamine lipid nanoparticles. PL53 exhibits outstanding transfection efficiency both in vitro and in vivo, especially showing strong protein expression ability and potential tissue targeting after intramuscular injection. PL53 can be used for the study of nucleic acid delivery.

Boc-protected photo-Leu(tBu) (compound 4) is a synthetic intermediate of diazirine-containing probe (photo-Met).

Cylic-DAP is a substrate of splenic cyclic phosphodiesterases.

Cyclic-di-DAP is a base-modified analog of c-di-AMP (HY-12326).

SIK1-IN-1 (Compound 27) is a selective Salt-inducible kinase 1 (SIK1) inhibitor with an IC₅₀ of 0.7  nM for SIK1 over SIK2 and SIK3. SIK1-IN-1 has no cytotoxicity against HEK293 cells and PBMCs (maximum concentration of 30 μM). SIK1-IN-1 also has potent inhibitory activities for 392 kinases, in particular tyrosine kinases, such as FGR, HCK and LYN).

HPPD/PPO-IN-1 (Compound B14) is dual-functional inhibitor of HPPD and PPO with IC₅₀s of 0.12  μM and 0.51 μM for Arabidopsis thaliana HPPD and Nicotiana tabacum PPO, respectively. HPPD/PPO-IN-1 has broad-spectrum herbicidal activity against weeds with a crop safety to peanuts and cotton. HPPD/PPO-IN-1 can be used for the development of environmentally friendly herbicides.

BRD4 ligand 13 is a BRD4 ligand that can be used for the synthesis of PROTACs, such as Cath-L-dBET1 (HY-173257). BRD4 ligand 13 is a target protein ligand-conjugate that can be used for the synthesis of PROTACs, such as SJH1-51B (HY-162240).

PPO-IN-21 (Compound A20) is a protoporphyrinogen IX oxidase (PPO) inhibitor with a K_i of 15.2 nM for Nicotiana tabacum PPO. PPO-IN-21 has inhibitory activity against various weeds (including monocots and dicots). PPO-IN-21 can be used as herbicide.

PPO-IN-22 (Compound B-04) is a benzothiazol-2(3H)-one derivative. PPO-IN-22 is a herbicide. PPO-IN-22 exhibits excellent post-emergence herbicidal activity against broadleaf weeds. PPO-IN-22 demonstrates potent pre-emergence activity against both dicotyledonous and monocotyledonous weeds. PPO-IN-22 exhibits favorable crop safety as a selective pre-emergence herbicide in soybean, peanut, and cotton cultivation systems.

JAX-44 is a potent root architecture modulator. JAX-44 maintains primary root length while substantially increasing lateral root numbers, thereby optimizing the plant’s overall root system. JAX-44 is the metabolic precursor of JAX-77 (HY-178359) and can be converted to Indole-3-butyric acid (IBA) (HY-N0186). JAX-44 can be used for auxin biology and root development research.

JAX-77 is a potent root architecture modulator. JAX-77 maintains primary root length while substantially increasing lateral root numbers, thereby optimizing the plant’s overall root system. JAX-77 is the key intermediate metabolite formed from the hydrolysis of JAX-44 (HY-178358) and can be converted to Indole-3-butyric acid (IBA) (HY-N0186). JAX-77 can be used for auxin biology and root development research.

(Rac)-IDO1-IN-30 is the Rac isomer of IDO1-IN-30 (HY-178479). IDO1-IN-30 is a potent and highly selective IDO1 inhibitor. IDO1-IN-30 has an IC₅₀ of 4.8 nM to IDO1 in SKOV3 cells. IDO1-IN-30 does not show significant cytotoxicity at 25 µM in HepG2 cells. IDO1-IN-30 can eliminate inhibition of CYP450 enzymes (such as 3A4, 2C9, 2D6). IDO1-IN-30 can be used for research on cancer and inflammatory conditions.