159954-97-9
Chemical Structure
3'-O-(2-Nitrobenzyl)-dATP
- CAS No.: 159954-97-9
- Formula:C17H21N6O14P3
- Molecular Weight:626.30
InChIKey: GWBBFXWEJPCIIJ-BFHYXJOUSA-N
SMILES: NC1=NC=NC2=C1N=CN2[C@H]3C[C@H](OCC4=CC=CC=C4[N+]([O-])=O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O3
Biological Activity: 3'-O-(2-Nitrobenzyl)-dATP is a reversible and photolabile DNA synthesis terminator. 3'-O-(2-Nitrobenzyl)-dATP incorporates into growing DNA strands to terminate synthesis in a base-specific manner. 3'-O-(2-Nitrobenzyl)-dATP undergoes efficient photolytic removal of its 3'-protecting group upon UV exposure to enable reinitiation of DNA synthesis. 3'-O-(2-Nitrobenzyl)-dATP supports development of the Base Addition Sequencing Scheme (BASS) via a complete stop-start DNA synthesis cycle[1].
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3'-O-(2-Nitrobenzyl)-dATP | 3'-O-(2-Nitrobenzyl)-dATP is a reversible and photolabile DNA synthesis terminator. 3'-O-(2-Nitrobenzyl)-dATP incorporates into growing DNA strands to terminate synthesis in a base-specific manner. 3'-O-(2-Nitrobenzyl)-dATP undergoes efficient photolytic removal of its 3'-protecting group upon UV exposure to enable reinitiation of DNA synthesis. 3'-O-(2-Nitrobenzyl)-dATP supports development of the Base Addition Sequencing Scheme (BASS) via a complete stop-start DNA synthesis cycle. | |||||||||||||||||||||
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