Others

Autophagy-IN-12 is a Autophagy inhibitor. Autophagy-IN-12 exhibits an IC₅₀ value of >33 μM against the protein-protein interactions of ATG5-ATG16L1 and ATG5-TECAIR.

NAIA (N-Acryloylindole-alkyne) is a cysteine-reactive probe. NAIA can be used as an imaging agent, proteome profiling agent, and covalent ligand screening tool.

Pefabloc PL is a plasmin inhibitor with submicromolar-range inhibitory activity against the trypsin-like serine protease plasmin.

N-(4-(1H-Pyrazol-1-yl) butyl)-5-(furan-2-yl) isoxazole-3-carboxamide is a cell culture medium component used for the long-term expansion of granulocyte/macrophage progenitor cells in culture.

LAF-153 is a Methionine Aminopeptidase-2 (MetAP-2) inhibitor with human IC₅₀ values of 0.074 μM and 0.16 μM.LAF-153 has a t-butyl group extending into the innermost portion of the MetAP-2 cleft, a lactam ring coordinated in the enzyme’s shallow surface pocket, and three hydroxyl groups coordinating to the two cobalt ions in the enzyme’s active site.

EphB1-IN-2 is a mutant-selective kinase inhibitor of ABL and FGFR4, with an IC₅₀ of 14 nM against ABL^G321C mutant and 163 nM against FGFR4^G556C mutant. EphB1-IN-2 shows selectively over wild-type ABL and FGFR4.

EPZ020809 is a competitive KDM4C inhibitor with a K_i of 31 nM.

H-D-Ala-β-Ala-OH is a synthetic alanyl dipeptide with no activity against Bacillus thiaminolyticus spore germination and no antibacterial activity against gram-positive and gram-negative bacteria at 100 μg/mL.

DSPE-PEG2000-tetrazine is a synthetic phospholipid modified with PEG2000 and tetrazine moieties. DSPE-PEG2000-tetrazine gains improved steric stability via PEGylation. DSPE-PEG2000-tetrazine enables bioorthogonal click chemistry through its tetrazine segment, which selectively reacts with trans-cyclooctene (TCO) under complex biological environments. DSPE-PEG2000-tetrazine can be applied for researches related to click chemistry.

Cyclo(L-Ser-L-Val) is a cyclic dipeptide (diketopiperazine) that lacks growth-promoting activity for E. coli in SAPI-serum medium.Cyclo(L-Ser-L-Val) can be chemically synthesized as a precursor to cyclo(ΔAla-L-Val).

Desaspidin is an oxidative phosphorylation inhibitor and photophosphorylation inhibitor. Desaspidin uncouples mitochondrial oxidative phosphorylation, multiple chloroplast photophosphorylation pathways, and ATP synthesis linked to non-cyclic NADP reduction. Desaspidin can be used for the research of anthelmintic agent.

YM-1 (TFA) is an inhibitor of angiotensin converting enzyme (ACE) that can be obtained from Chrysanthemum boreale Makino.

Alanyl ornithine is a PEPT1 (mammalian H⁺/peptide cotransporter) ligand with a binding affinity for this transporter (K_i = 0.97 mM). Alanyl ornithine serves as a reference molecule for studies on the substrate recognition mechanism of PEPT1.

Pinazaphilone A is a type of polyketide compound derived from the mangrove endophytic fungus Penicillium sp.

10-Fluoro-1-phenyldecan-1-one is a fluoroalkyl phenyl ketone.

Carboxylesterase 2-IN-1 is a potent carboxylesterase CES2 inhibitor with an IC₅₀ of 0.13 μM. Carboxylesterase 2-IN-1 blocks the hydrolysis of fluorescein diacetate by CES2 via non-competitive inhibition. Carboxylesterase 2-IN-1 also effectively inhibits adipogenesis induced in mouse preadipocytes.

5S rRNA modificator is a suitable electrophile for 2’-hydroxyl acylation on structured RNA molecules, yielding accurate structural information comparable to that obtained with existing probes; 5S rRNA RNA modification.

Sigma-2 Receptor ligand 2 is a fluorescence labeled sigma-2 ligand. Sigma-2 Receptor ligand 2 can be used as a fluorescent probe.

1-(1-(2-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)ethyl)-5-(trifluoromethoxy)-1H-indol-3-yl)-2-(4-chloro-2-methoxyphenyl)-2-((3-methoxy-5-(2-methoxyethoxy)phenyl)amino)ethan-1-one is a click chemistry reagent containing an alkyne group, and it can be used in click chemistry applications.

Photoclick stearic acid is a bifunctional lipid probe derived from stearic acid, containing a photo-activatable diazirine group and a terminal clickable alkyne moiety. Photoclick stearic acid can be used as a chemical reporter to investigate protein lipidation and analyze membrane protein-protein interactions.