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RAR/RXR Related Products (156)
Related Products (156)
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TTNPB
0 ImagesSynonyms: Ro 13-7410; Arotinoid acid; AGN191183TTNPB is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC50s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively.
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Bexarotene
0 ImagesSynonyms: LGD1069
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AM580
0 ImagesSynonyms: CD336; NSC608001; Ro 40-6055AM580 is a selective RARα agonist with IC50 and EC50 of 8 nM and 0.36 nM, respectively.
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Tamibarotene
0 ImagesSynonyms: Am 80Tamibarotene is an orally active retinoic acid receptor α (RARα) agonist, showing high selectivity over RARγ.
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AGN 193109
0 ImagesAGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. AGN 193109 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity.
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XCT0135908
0 ImagesCat. No.: HY-119612CAS No.: 300837-31-4Synonyms: XCTXCT0135908 (XCT) is a selective Nurr1-RXRα activator with an EC50 value of 0.3 μM in human dopaminergic SH-SY5Y cells. XCT0135908 protects dopaminergic cells against the Parkinson’s disease-related toxin MPP+. XCT0135908 can be used for the research of Parkinson’s disease.
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Trifarotene-d4
0 ImagesCat. No.: HY-100256SSynonyms: CD5789-d4Trifarotene-d4 (Cd5789-d4) is the deuterium labeled Trifarotene (HY-100256). Trifarotene (CD5789) is a potent and selective RARγ agonist. Trifarotene (CD5789) shows ～65-fold and ～16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM), respectively.
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Adapalene
0 ImagesSynonyms: CD271Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity.
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Fenretinide
0 ImagesSynonyms: 4-HPR; ISLA-101Fenretinide (4-HPR) is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.
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Palovarotene
0 ImagesSynonyms: R 667; Ro 3300074Palovarotene is a nuclear retinoic acid receptor γ (RAR-γ) agonist.
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Oxybenzone
0 ImagesOxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.
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Acitretin
0 ImagesSynonyms: Ro 10-1670Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. Acitretin also can be used for the research of Alzheimer’s disease.
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Tazarotene
0 ImagesSynonyms: AGN 190168Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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LG100268
0 ImagesSynonyms: LG268LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC50 values of 4 nM, 3 nM, and 4 nM for RXR-α, RXR-β, and RXR-γ, respectively. LG100268 displays >1000-fold selectivity for RXR over RAR, the Ki values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-α, RXR-β, and RXR-γ, respectively. LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy.
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Retinoic acid (GMP)
0 ImagesSynonyms: Vitamin A acid (GMP); all-trans-Retinoic acid (GMP); ATRA (GMP)Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors.
