1. Metabolic Enzyme/Protease
    Autophagy
  2. RAR/RXR
    Autophagy
  3. LY2955303

LY2955303 

Cat. No.: HY-107765 Purity: 99.16%
Handling Instructions

LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM.

For research use only. We do not sell to patients.

LY2955303 Chemical Structure

LY2955303 Chemical Structure

CAS No. : 1433497-19-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
5 mg USD 216 In-stock
Estimated Time of Arrival: December 31
10 mg USD 372 In-stock
Estimated Time of Arrival: December 31
25 mg USD 828 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM.

IC50 & Target

Ki: 1.09 nM (RARγ)[1]

In Vitro

LY2955303 is tested and observed that the binding Kis for RARα, RARβ and RARγ are >1700, >2980 and 1.09 nM, respectively. The functional Ki for RARγ is 7.1±4.9 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A single oral dose of LY2955303 demonstrates a dose responsive effect whereby the rat reduces differential weight bearing (ED50=0.72 mg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

578.74

Formula

C₃₆H₄₂N₄O₃

CAS No.

1433497-19-8

SMILES

CC(C)(C1=CC(C(C)(C)C)=CC(C2=CC(C3=CC=C(C(O)=O)C=C3)=NN2C4=CC=C(C(N5CCN(C)CC5)=O)C=C4)=C1)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (51.84 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7279 mL 8.6395 mL 17.2789 mL
5 mM 0.3456 mL 1.7279 mL 3.4558 mL
10 mM 0.1728 mL 0.8639 mL 1.7279 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2 mg/mL (3.46 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (3.46 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

LY2955303LY 2955303LY-2955303RAR/RXRAutophagyRetinoic acid receptorsRetinoid X receptorsInhibitorinhibitorinhibit

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Product Name:
LY2955303
Cat. No.:
HY-107765
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