144092-31-9
Chemical Structure
Ro 41-5253
- CAS No.: 144092-31-9
- Formula:C28H36O5S
- Molecular Weight:484.65
IUPAC Name: (E)-4-(2-(7-(heptyloxy)-4,4-dimethyl-1,1-dioxidothiochroman-6-yl)prop-1-en-1-yl)benzoic acid
InChIKey: JEIWQRITHXYGIF-LVZFUZTISA-N
SMILES: O=C(C1=CC=C(C=C1)/C=C(C)/C2=C(C=C3C(C(C)(CCS3(=O)=O)C)=C2)OCCCCCCC)O
Biological Activity: Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RARα) antagonist. Ro 41-5253 can bind RARα without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity[1][2].
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Ro 41-5253 | 98.97% | Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RARα) antagonist. Ro 41-5253 can bind RARα without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity. | ||||||||||||||||||||
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- [1]. S Toma, et al. RARalpha antagonist Ro 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines. Int J Cancer. 1998 Sep 25;78(1):86-94 [Content Brief]
- [2]. Salvatore Toma, et al. Retinoids and human breast cancer: in vivo effects of an antagonist for RAR-alpha. Cancer Lett. 2005 Feb 28;219(1):27-31. doi: 10.1016/j.canlet.2004.06.018. [Content Brief]
Keywords
