Retinoids and human breast cancer: in vivo effects of an antagonist for RAR-alpha

  • Cancer Lett. 2005 Feb 28;219(1):27-31. doi: 10.1016/j.canlet.2004.06.018.
Salvatore Toma  1 ,  Laura Emionite ,  Angelo Scaramuccia ,  Giambattista Ravera ,  Linda Scarabelli
Affiliations
  • 1. Department of Oncology, Biology and Genetics, University of Genoa, Genoa, Italy. [email protected]
PMID: 15694661 DOI: 10.1016/j.canlet.2004.06.018
Abstract

The aim of the present study was to evaluate the in vivo effects of the RAR-alpha selective antagonist Ro 41-5253 on a xenograft animal model for breast Cancer. Our observations indicate a lack of toxic side effects of the drug, even when used at high dosages. It is interesting to note that using Ro 41-5253 at dosages of 10, 30 and 100 mg/kg/die resulted in a slight, but significant inhibition of cell growth. The data obtained in this study represents the basis for a further evaluation of Ro 41-5253 anti-neoplastic activity on transgenic breast Cancer animal models.

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