2. Signaling Pathways
  3. Anti-infection
  4. SARS-CoV

SARS-CoV

SARS coronavirus

SARS-CoV

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SARS-CoV is the coronavirus (CoV) that causes severe acute respiratory syndrome (SARS). CoVs are enveloped viruses with a positive-sense, single-stranded RNA and can cause health-threatening outbreaks by targeting human respiratory system, including not only SARS, but also Middle East respiratory syndrome (MERS) and SARS-CoV-2 (the cause of COVID-19).

CoVs have four main structural proteins: spike(S), membrane (M), envelope (E), and nucleocapsid (N) proteins. An S protein mediates the CoV entry into host cells by attaching to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), followed by fusion between virus and host cell membranes. Genome replication and subgenomic RNA transcription after entry carry on with the participation of many nonstructural proteins such as Mpro (main protease or 3CLpro), PLpro (papain-like protease) and RdRp (RNA-dependent RNA polymerase). Then the structural proteins are translated, assembled into mature virions, and released via vesicles by exocytosis. It is worth mentioning that a protease called TMPRSS2 (transmembrane protease, serine 2) play important roles throughout the whole life of CoVs (such as attachment, assembling and release) by cleaving S protein. All the proteins and subcellular structures participated in the life cycle of CoVs are promising targets for treatment of disease caused by CoVs.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-157144
    SARS-CoV-2-IN-68
    		Inhibitor
    SARS-CoV-2-IN-68 (compound 6C) is a covalent SARS-CoV-2 PLpro/Mpro inhibitor with potent antiviral activities. SARS-CoV-2-IN-68 binds to Zn-finger domain of PLpro.
    SARS-CoV-2-IN-68
  • HY-124654
    SS148
    		Inhibitor
    SS148 is a dual inhibitor of nsp14/nsp16 MTase. SS148 significant inhibits nsp10–nsp16 with an IC50 of 1.2 μM.
    SS148
  • HY-W012531S2
    2-Hydroxycinnamic acid-d4
    		Inhibitor
    2-Hydroxycinnamic acid-d4 is deuterium labeled 2-Hydroxycinnamic acid. 2-Hydroxycinnamic acid is a phenolic acid with antimicrobial and antioxidant properties. 2-Hydroxycinnamic acid has antimicrobial activity against Staphylococcus aureus and is not susceptible to drug resistance. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC50 of 0.3 mM. In addition, 2-Hydroxycinnamic acid has neuroprotective and antitumor activity.
    2-Hydroxycinnamic acid-d<sub>4</sub>
  • HY-161837
    SARS-CoV-2 Mpro-IN-24
    		Inhibitor
    SARS-CoV-2 Mpro-IN-24 (Compound X77) is a inhibitor of SARS-CoV-2 Mpro (IC50=2.8 μM) and also a non-covalent inhibitor of SARS-CoV Mpro (IC50=3.4 μM).
    SARS-CoV-2 Mpro-IN-24
  • HY-163627
    SARS-CoV-2 Mpro-IN-19
    		Inhibitor
    SARS-CoV-2 Mpro-IN-19 (compound MPI94) is a SARS-CoV-2 MPro inhibitor with the IC50 of 0.096 μM. SARS-CoV-2 Mpro-IN-19 can be used for study of COVID-19.
    SARS-CoV-2 Mpro-IN-19
  • HY-168917
    9-Aminominocycline
    		Inhibitor
    9-Aminominocycline (9-AMN) is the inhibitor for SARS-CoV-2 papain-like protease (SARS-CoV-2 PLpro), inhibits its deubiquitination (DUB) activity and protease activity with IC50 of 4.55 µM and 4.15 µM. 9-Aminominocycline inhibits the SARS-CoV variants Delta and Omicron replication in Calu-3 cell with IC50 of 1.04 µM and 2.35 µM.
    9-Aminominocycline
  • HY-10238R
    Danoprevir (Standard)
    		Inhibitor
    Danoprevir (Standard) is the analytical standard of Danoprevir (HY-10238). This product is intended for research and analytical applications. Danoprevir (ITMN-191) is an orally active NS3/4A protease inhibitor for hepatitis C virus (HCV) with an IC50 of 0.29 nM and is selective for NS3/4A over a panel of 53 proteases (IC50 higher than 10 μM). Danoprevir (ITMN-191) inhibits HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s=0.2-0.4 nM) as well as 2b and 3a (IC50s=1.6, 3.5 nM). Danoprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 0.05 μM.
    Danoprevir (Standard)
  • HY-170886
    SARS-CoV-2 Mpro-IN-36
    		Inhibitor
    SARS-CoV-2 Mpro-IN-36 (Compound 6d) is an inhibitor of SARS-CoV-2 Mpro with an IC50 of 110 nM. SARS-CoV-2 Mpro-IN-36 exhibits antiviral activity with an EC50 of 1.6 μM.
    SARS-CoV-2 Mpro-IN-36
  • HY-174251
    (±)-Tuaimenal A
    		Inhibitor
    (±)-Tuaimenal A ((+)-1) is a secondary metabolite and a derivative of Sesamol (HY-N1417). (±)-Tuaimenal A has potent inhibitory activity against SARS-CoV-2 3CLpro with an IC50 of 33.3  μM. (±)-Tuaimenal A can be used for SARS-CoV-2 infection research.
    (±)-Tuaimenal A
  • HY-163908
    SARS-CoV-2-IN-94
    		Inhibitor
    SARS-CoV-2-IN-94 (Compound 6) exhibits antiviral activity against COVID-19 virus by targeting 6VSB protein.
    SARS-CoV-2-IN-94
  • HY-177910
    Anticoronavirus agent-1
    		Inhibitor
    Anticoronavirus agent-1 (Compound IV-2) is a 1,4-naphthone compound and is a 3CL hydrolase inhibitor (3C-like proteinase) of the 19-nCoV novel coronavirus. Anticoronavirus agent-1 has low cytotoxity on HSF cells. Anticoronavirus agent-1 can be used for the study of the novel coronavirus.
    Anticoronavirus agent-1
  • HY-168472
    13-TP prodrug
    		Inhibitor
    13-TP prodrug (compound 15) is a potent and orally active anti-SARS-CoV-2 agent. 13-TP prodrug shows cytotoxicity. 13-TP prodrug decreases the SARS-CoV-2 N protein expression. 13-TP prodrug shows antiviral activity.
    13-TP prodrug
  • HY-180910
    SARS-CoV-2 Mpro-IN-53
    SARS-CoV-2 Mpro-IN-53 (Compound 7) is a SARS-CoV-2 Mpro inhibitor. SARS-CoV-2 Mpro-IN-53 causes a decrease in Mpro radius of gyration.
    SARS-CoV-2 Mpro-IN-53
  • HY-159477
    SARS-CoV-2-IN-92
    		Inhibitor
    SARS-CoV-2-IN-92 (compound 11) inhibits SARS-CoV-2 variants (EC50 = 0.48 μM), as well as SARS-CoV and MERS-CoV. SARS-CoV-2-IN-92 (compound 11) potently and selectively blocks ERα-Glu II.
    SARS-CoV-2-IN-92
  • HY-17443BR
    Sivelestat sodium tetrahydrate (Standard)
    Sivelestat (sodium tetrahydrate) (Standard) is the analytical standard of Sivelestat (sodium tetrahydrate). This product is intended for research and analytical applications. Sivelestat (EI546) sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
    Sivelestat sodium tetrahydrate (Standard)
  • HY-158905
    MTDB-Alkyne
    		Degrader
    MTDB-Alkyne is an alkyne-containing click chemistry reagent. MTDB-Alkyne can be used to synthesize Proximity-Induced Nucleic Acid Degrader (PINAD) for the degradation of SARS-CoV-2 RNA.
    MTDB-Alkyne
  • HY-179612
    SARS-CoV-2 3CLpro-IN-34
    		Inhibitor
    SARS-CoV-2 3CLpro-IN-34 (Compound 55) is a highly efficient non-covalent inhibitor of the SARS-CoV-2 3CLpro protease (b. SARS-CoV-2 3CLpro protease) with an IC50 of 1.9 μM. SARS-CoV-2 3CLpro-IN-34 can inhibit the 3CLpro protein of SARS-CoV-1, with its IC50 being 3.2 μM, and it shows high selectivity towards host cysteine proteases (such as cathepsins L/K and calpain). SARS-CoV-2 3CLpro-IN-34 exhibits antiviral activity in cells infected with SARS-CoV-2, with its EC50 being 25 μM, and it is not affected by P-gp inhibitors and shows no significant cytotoxicity. SARS-CoV-2 3CLpro-IN-34 can be used for research on SARS-CoV-2 infection.
    SARS-CoV-2 3CLpro-IN-34
  • HY-126085R
    (±)-Alliin (Standard)
    		Inhibitor
    (±)-Alliin (Standard) is the analytical standard of (±)-Alliin. This product is intended for research and analytical applications. (±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (Mpro).
    (±)-Alliin (Standard)
  • HY-180458
    SARS-CoV-2 Mpro-IN-52
    		Inhibitor
    SARS-CoV-2 Mpro-IN-52 (compound 47) is a potent SARS-CoV-2 main protease (MPro) inhibitor (EC50 = 0.0099 µM) with antiviral activity. SARS-CoV-2 Mpro-IN-52 exhibits potent and broad-spectrum activity against MERS, OC43, 229E with EC50s of 0.00961, 0.138, and 0.117 µM. SARS-CoV-2 Mpro-IN-52 can be used for COVID-19 research.
    SARS-CoV-2 Mpro-IN-52
  • HY-183727
    SARS-CoV-2 Mpro-IN-59
    		Inhibitor
    SARS-CoV-2 Mpro-IN-59 is a competitive, nonpeptidic SARS-CoV-2 Mpro inhibitor. SARS-CoV-2 Mpro-IN-59 can be used for the research of covid-19.
    SARS-CoV-2 Mpro-IN-59
Cat. No. Product Name / Synonyms Species Source