2. Anti-infection
  3. SARS-CoV Virus Protease
  4. SARS-CoV-2 PLpro-IN-6

SARS-CoV-2 PLpro-IN-6 is an irreversible SARS-CoV-2 papain-like protease inhibitor with an IC50 value of 0.059 μM. SARS-CoV-2 PLpro-IN-6 exhibits antiviral activity and can be used in studies related to COVID-19.

For research use only. We do not sell to patients.

SARS-CoV-2 PLpro-IN-6

SARS-CoV-2 PLpro-IN-6 Chemical Structure

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SARS-CoV-2 PLpro-IN-6 Related Antibodies

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Description

SARS-CoV-2 PLpro-IN-6 is an irreversible SARS-CoV-2 papain-like protease inhibitor with an IC50 value of 0.059 μM. SARS-CoV-2 PLpro-IN-6 exhibits antiviral activity and can be used in studies related to COVID-19[1].

In Vitro

SARS-CoV-2 PLpro-IN-6 (compound 45) (5-60 min) inhibits recombinant SARS-CoV-2 PLPro in a time-dependent manner, with an IC50 of 0.059 μM after 60 min of incubation[1].
SARS-CoV-2 PLpro-IN-6 (48 h) exhibits antiviral activity against SARS-CoV-2 in A549 cells, with an EC50 of 2.1 μM at 48 hpi, and shows no cytotoxicity at concentrations up to 100 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SARS-CoV-2 PLpro-IN-6 Related Antibodies
Molecular Weight

658.74

Formula

C36H40F2N6O4
SMILES

CC1=C2OC3(CCC2=CC=C1C4=CC=NC(C)=C4)CCN(CC3)CC5=C(C=CC=N5)CCC(NNC(/C=C/C(N6CC(F)(C6)F)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SARS-CoV-2 PLpro-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2 PLpro-IN-6SARS-CoVVirus ProteaseSARS coronaviruslung epithelial cellsA549 cellscovid-19SARS-CoV-2 papain-like proteaseInhibitorinhibitorinhibit

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