Smo
Smoothened
Smoothened (Smo), a class Frizzled G protein-coupled receptor (class F GPCR), transduces the Hedgehog (Hh) signal across the cell membrane. The Hh signaling pathway includes both canonical and noncanonical pathways. The canonical Hh pathway functions through major Hh molecules such as Hh ligands, PTCH, Smo, and GLI, whereas the noncanonical Hh pathway involves the activation of Smo or GLI through other pathways.
The Hh signaling cascade is initiated by the binding of the Hh protein ligand to its cellular membrane receptor, Patched (PTCH), which relieves PTCH-mediated repression of the seven-transmembrane (7TM) protein Smo. Activated Smo transduces the signal to the GLI family of transcription factors, which translocate to the nucleus to regulate numerous gene products involved in tissue patterning and cell differentiation.
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Smo Related Products (82)
Related Products (82)
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PF-5274857 hydrochloride
0 ImagesCat. No.: HY-13459ACAS No.: 1613439-62-5PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.
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RL-0070933
0 ImagesCat. No.: HY-148440CAS No.: 301326-41-0
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Antibacterial agent 189
0 ImagesCat. No.: HY-162273Antibacterial agent 189 (compound 3a) is a potent antimicrobial agent. Antibacterial agent 189 offers high binding energy against the target OMPA/exo-1,3-beta-glucanase proteins. Antibacterial agent 189 exhibits the potent antimicrobial activities against E. coli, P. aeruginosa, S. aureus, B. subtilis, C. Albicans and A. flavus. Antibacterial agent 189 shows high binding energy against target SMO and SUFU/GLI-1 proteins.
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Halcinonide (Standard)
0 ImagesHalcinonide (Standard) is the analytical standard of Halcinonide. This product is intended for research and analytical applications. Halcinonide (SQ-18566) is a high potency corticosteroid used topically in the treatment of certain skin conditions.
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SAG (GMP)
0 ImagesCat. No.: HY-12848GCAS No.: 912545-86-9
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MK-4101 (Standard)
0 ImagesCat. No.: HY-100036RCAS No.: 935273-79-3MK-4101 (Standard) is the analytical standard of MK-4101 (HY-100036). This product is intended for research and analytical applications. MK-4101 is a Smoothened (SMO) antagonist (IC50 of 1.1 μM for 293 cells ) and also a potent inhibitor of the hedgehog pathway (IC50 of 1.5 μM for mouse cells; IC50 of 1 μM for KYSE180 oesophageal cancer cells). MK-4101 has robust antitumor activity that inhibits tumor cell proliferation and induces extensive apoptosis.
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Sonidegib (Standard)
0 ImagesSynonyms: Erismodegib (Standard); LDE225 (Standard); NVP-LDE225 (Standard)Sonidegib (Standard) is the analytical standard of Sonidegib. This product is intended for research and analytical applications. Sonidegib (Erismodegib) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively.
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IHR-1 (Standard)
0 ImagesCat. No.: HY-110240RCAS No.: 548779-60-8IHR-1 (Standard) is the analytical standard of IHR-1 (HY-110240). This product is intended for research and analytical applications. IHR-1 is a cell membrane impermeable Smo antagonist.
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N1-Acetyl triethylenetetramine
0 ImagesCat. No.: HY-W700539CAS No.: 141998-21-2N1-Acetyl triethylenetetramine is a polyamine derivative with a free amino terminus. N1-Acetyl triethylenetetramine serves as a substrate for spermidine/spermine N1-acetyltransferase (SSAT) and exerts competitive inhibitory effects on APAO and SMO. N1-Acetyl triethylenetetramine can be catalyzed to undergo acetylation by recombinant mouse SSAT. It is applicable in metabolism-related research.
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Glasdegib (Standard)
0 ImagesCat. No.: HY-16391RCAS No.: 1095173-27-5Synonyms: PF-04449913 (Standard)Glasdegib (Standard) is the analytical standard of Glasdegib. This product is intended for research and analytical applications. Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM.
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MS-0022
0 ImagesCat. No.: HY-123752CAS No.: 691392-89-9
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MRT-10 (Standard)
0 ImagesCat. No.: HY-108507RCAS No.: 330829-30-6MRT-10 (Standard) is the analytical standard of MRT-10 (HY-108507). This product is intended for research and analytical applications. MRT-10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC50 of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT-10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT-10 can be used for the research of cancer.
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Clobetasol
0 ImagesCat. No.: HY-W338819CAS No.: 25122-41-2Clobetasol is a glucocorticoid and Smoothened agonist that can cross the blood-brain barrier. Clobetasol induces Smo-dependent activation of the Shh signaling pathway and nuclear translocation of Gli1. Clobetasol promotes remyelination and reduces myelin loss in lesions of neuromyelitis optica (NMO). Clobetasol may cause adrenal suppression, cushingoid appearance, and local adverse reactions including dysgeusia, xerostomia, and gastroesophageal burning. Clobetasol can be used in research related to neurodegenerative diseases, oral lichen planus, mucous membrane pemphigoid, and neuromyelitis optica.
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MRT-92
0 ImagesCat. No.: HY-117903ACAS No.: 1428315-82-5MRT-92 is a Smoothened (Smo) antagonist (Ki=0.7 nM) with anticancer activity. MRT-92 inhibits Hedgehog signaling pathway and rodent cerebellar granule cell proliferation by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor (IC50=0.4 nM). MRT-92 can be used in the study of cerebellar glioma.
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Anti-FZD7 Antibody
0 ImagesCat. No.: HY-P990418The Anti-FZD7 Antibody is a human-derived antibody expressed in CHO, targeting FZD7. The Anti-FZD7 Antibody is composed of a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-FZD7 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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MDB5
0 ImagesCat. No.: HY-184378CAS No.: 2922221-22-3MDB5 is a Hedgehog pathway and Smoothened inhibitor that binds to the 7-TM domain of Smo. MDB5 reduces hepatic stellate cell activation, extracellular matrix-related gene expression, collagen deposition, hydroxyproline content and epithelial-mesenchymal transition, and prevents sinusoidal endothelial cell capillarization. MDB5 induces G1 and S phase cell cycle arrest, triggers apoptosis by upregulating Bax and downregulating Bcl-2, and also decreases oxygen consumption rate, glucose uptake, transglutaminase activity and fibronectin matrix assembly. MDB5 reduces the levels of liver injury markers, hepatic triglyceride deposition and hepatic steatosis, restores the tissue structure of the kidney and spleen, and inhibits pancreatic tumor growth without causing body weight loss. MDB5 can be loaded into PEG-PCC-g-DC micelles, achieving high drug loading, sustained release, improved water solubility, enhanced cellular uptake and optimized hepatic distribution, with good tolerance in mice. MDB5 is applicable to research related to alcohol-associated liver disease, liver fibrosis and pancreatic cancer.
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SMO-IN-2
0 ImagesSMO-IN-2 is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity.
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7-keto-25-Hydroxycholesterol
0 ImagesCat. No.: HY-133974CAS No.: 64907-23-9Synonyms: 7-keto-25-OHC
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Saridegib hydrochloride
0 ImagesCat. No.: HY-16587ACAS No.: 1169829-40-6Synonyms: IPI 926 hydrochloride; Patidegib hydrochloride
