1095173-27-5
1095173-27-5
Chemical Structure
Glasdegib
Synonym(s): PF-04449913
- CAS No.: 1095173-27-5
- Formula:C21H22N6O
- Molecular Weight:374.44
IUPAC Name: 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea
InChIKey: SFNSLLSYNZWZQG-VQIMIIECSA-N
SMILES: O=C(NC1=CC=C(C#N)C=C1)N[C@H]2C[C@H](C3=NC4=CC=CC=C4N3)N(C)CC2
Biological Activity: Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Glasdegib | 99.65% | Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM. | ||||||||||||||||||||
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Glasdegib (Standard) | ≥98% | Glasdegib (Standard) is the analytical standard of Glasdegib. This product is intended for research and analytical applications. Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM. | ||||||||||||||||||||
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Glasdegib-d4 | Glasdegib-d4 (PF-04449913-d4) is deuterium labeled Glasdegib. Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM. | |||||||||||||||||||||
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