1613439-62-5
Chemical Structure
PF-5274857 hydrochloride
- CAS No.: 1613439-62-5
- Formula:C20H26Cl2N4O3S
- Molecular Weight:473.42
IUPAC Name: 1-(4-(5'-chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one hydrochloride
InChIKey: GULNFUQAVPTTQV-UHFFFAOYSA-N
SMILES: O=C(N1CCN(C2=NC=C(Cl)C(C3=NC=C(C)C=C3C)=C2)CC1)CCS(=O)(C)=O.Cl
Biological Activity: PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway[1].
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PF-5274857 hydrochloride | PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway. | |||||||||||||||||||||
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Keywords
