Drug Intermediate
Drug Iintermediate
Drug intermediates are used as raw materials for the production of bulk drugs, or they can refer to a material produced during synthesis of an API that must undergo further molecular change or processing before it becomes an API. Drug intermediates are hygienically formulated using high grade raw materials and they are used in the pharmaceutical and cosmetic industry[1][2].
References:
- [1]. Ma HC, et al. Homochiral Covalent Organic Framework for Catalytic Asymmetric Synthesis of a Drug Intermediate. J Am Chem Soc. 2020 Jul 22;142(29):12574-12578. [Content Brief]
- [2]. Ramachary D B, et al. Development of pharmaceutical drugs, drug intermediates and ingredients by using direct organo‐click reactions[J]. 2008.
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Drug Intermediate Related Products (4632)
Related Products (4632)
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Phenylglyoxylic acid-d5
0 ImagesSynonyms: Benzoylformic acid-d5Phenylglyoxylic acid-d5 (Benzoylformic acid-d5) is a deuterium labeled Phenylglyoxylic acid (HY-W010255). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human. Phenylglyoxylic acid can be used as drug intermediate for synthesis of antineoplastic compounds.
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D-Lyxose
0 ImagesD-Lyxose is an endogenous metabolite. D-Lyxose is a rare pentose with significant potential for pharmaceutical synthesis. D-Lyxose serves as a starting material for antitumor agents (such as α-galactosylceramide-based immunostimulants). D-Lyxose acts as a precursor for L-nucleoside analogs used in the development of antiviral drugs. D-Lyxose can be used as a synthetic intermediate for other rare sugars (such as L-ribose).
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5-Bromo-3-fluoropicolinic acid
0 ImagesCat. No.: HY-W005596CAS No.: 669066-91-5Synonyms: 5-Bromo-3-fluoropyridine-2-carboxylic acid5-Bromo-3-fluoropicolinic acid (5-Bromo-3-fluoropyridine-2-carboxylic acid) is a drug synthesis intermediate that can be used to synthesize an inhibitor of glycinamide ribonucleotide formyltransferase.
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Paliperidone impurity 15
0 ImagesCat. No.: HY-75261CAS No.: 84163-13-3Paliperidone impurity 15 is an impurity of Paliperidone.
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Dibutyl maleate
0 ImagesDibutyl maleate, the diester of the Maleic Acid, can be used as an intermediate of pharmaceutical synthesis. Dibutyl maleate can enhance contact sensitization to Fluorescein isothiocyanate in mice.
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FTC-146 precursor
0 ImagesFTC-146 precursor (Compound s6) is a drug intermediate that can be used to prepare σ-1 receptor positron emission tomography tracers ([¹⁸F]FTC-146).
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4-Fluororesorcinol
0 Images4‑Fluororesorcinol is a class of fluorinated resorcinol aromatic small molecules that participates in fluorescence-generating chemical reactions under alkaline conditions. 4‑Fluororesorcinol undergoes a fluorescence-generating reaction with dopamine in an alkaline aqueous solution system to produce an azacyclooctane derivative that emits blue fluorescence. 4‑Fluororesorcinol serves as a building block for fluorescent dyes.
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16α,17α-Epoxyprogesterone
0 Images16α,17α-Epoxyprogesterone is an important steroid, serving as an intermediate for many hormonal drugs such as Hydrocortisone (HY-N0583) and Megestrol (HY-B1834). 16α,17α-Epoxyprogesterone can further biotransform into another significant intermediate, 11α-hydroxy-16α,17α-epoxyprogesterone, to manufacture additional compounds.
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3-Acetylaniline
0 ImagesSynonyms: 3'-Aminoacetophenone3-Acetylaniline (3'-Aminoacetophenone) is a drug intermediate that can be used for the synthesis of quinoline derivatives.
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Fosmetpantotenate
0 ImagesSynonyms: RE-024Fosmetpantotenate is a phosphopantothenic acid (PPA) precursor designed to release PPA intracellularly, leading to restoration of CoA levels. Fosmetpantotenate is used to research pantothenate kinase-associated neurodegeneration.
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4-Bromo-3-fluorobenzaldehyde
0 Images4-Bromo-3-fluorobenzaldehyde is a drug intermediate that can be used for the synthesis of triaryl dimer antibacterial compounds.
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Diformylphloroglucinol
0 ImagesDiformylphloroglucinol is an acylphloroglucinol compound that can be used in the synthesis of Psiguadial B. Psiguadial B is a neuroprotective agent.
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Mal-PEG12-DOTA
0 ImagesCat. No.: HY-164731Mal-PEG12-DOTA is a RDC linker that can be used for the synthesis of RDC.
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Daunomycinone
0 ImagesSynonyms: NSC-109351Daunomycinone (NSC-109351) is a metabolite of Daunomycin (HY-13062A) and anticancer intermediate. Daunomycinone binds to nucleic acids synergistically with metal ions. Daunomycinone can be used in the research of leukemia.
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Atorvastatin acetonide tert-butyl ester
0 ImagesAtorvastatin acetonide tert-butyl ester is a useful pharmaceutical intermediate in the preparation of Atorvastatin salts. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.
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(R,S,S,R,S)-Boc-Dap-NE
0 ImagesCat. No.: HY-78931ACAS No.: 2994330-72-0(R,S,S,R,S)-Boc-Dap-NE is the inactive isomer of Boc-Dap-NE (HY-78931), and can be used as an experimental control. Boc-Dap-NE, is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.
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AFP464 dihydrochloride
0 ImagesCat. No.: HY-16031BPurity: 99.45%Synonyms: NSC710464 dihydrochlorideAFP464 (NSC710464) dihydrochloride is a prodrug of Aminoflavone (HY-132974) and an agonist of the aryl hydrocarbon receptor (AhR). AFP464 dihydrochloride downregulates the expression of α6-integrin (α6-integrin), inhibits breast tumor growth, reduces the population of tumor-initiating cells, disrupts mammosphere structure, induces the formation of mucin lake clusters, triggers DNA damage, and exerts antiproliferative activity. AFP464 dihydrochloride is rapidly converted to Aminoflavone by nonspecific esterases in plasma and cell culture media. AFP464 dihydrochloride is applicable to research related to breast cancer.
