21794-55-8
21794-55-8
Chemical Structure
Daunomycinone
Synonym(s): NSC-109351
- CAS No.: 21794-55-8
- Formula:C21H18O8
- Molecular Weight:398.36
IUPAC Name: (8S,10S)-8-acetyl-6,8,10,11-tetrahydroxy-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
InChIKey: YOFDHOWPGULAQF-MQJDWESPSA-N
SMILES: O=C(C1=CC=CC(OC)=C1C2=O)C3=C2C(O)=C4[C@H](C[C@](C(C)=O)(CC4=C3O)O)O
Biological Activity: Daunomycinone (NSC-109351) is a metabolite of Daunomycin (HY-13062A) and anticancer intermediate. Daunomycinone binds to nucleic acids synergistically with metal ions. Daunomycinone can be used in the research of leukemia[1][2][3][4][5].
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Daunomycinone | 98.89% | Daunomycinone (NSC-109351) is a metabolite of Daunomycin (HY-13062A) and anticancer intermediate. Daunomycinone binds to nucleic acids synergistically with metal ions. Daunomycinone can be used in the research of leukemia. | ||||||||||||||||||||
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Daunomycinone (Standard) | ≥98% | Daunomycinone (Standard) is the analytical standard of Daunomycinone (HY-114658). This product is intended for research and analytical applications. Daunomycinone (NSC-109351) is a metabolite of Daunomycin (HY-13062A) and anticancer intermediate. Daunomycinone binds to nucleic acids synergistically with metal ions. Daunomycinone can be used in the research of leukemia. | ||||||||||||||||||||
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References
- [1]. Herman EH, et al. Modification of some of the toxic effects of daunomycin (NSC-82,151) by pretreatment with the antineoplastic agent ICRF 159 (NSC-129,943). Toxicol Appl Pharmacol. 1974 Mar;27(3):517-26. [Content Brief]
- [2]. Tan C, et al. Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia. Cancer. 1967 Mar;20(3):333-53. [Content Brief]
- [3]. Baer H H, et al. Synthesis and biological activity of (S)-2′-fluorodaunorubicin. Canadian journal of chemistry, 1988, 66(1): 187-190.
- [4]. Aligiannis N, et al. Synthesis and cytotoxic activity of a new potent daunomycinone derivative. Bioorg Med Chem Lett. 2002 Dec 16;12(24):3505-7. [Content Brief]
- [5]. Mikelens P, et al. Metal ion participation in binding of daunomycinone, daunomycin, and adriamycin to nucleic acids. Bioinorganic Chemistry, 1978, 9(5): 441-452.
