Synthesis and cytotoxic activity of a new potent daunomycinone derivative

  • Bioorg Med Chem Lett. 2002 Dec 16;12(24):3505-7. doi: 10.1016/s0960-894x(02)00823-5.
Nectarios Aligiannis  1 ,  Nicole Pouli ,  Panagiotis Marakos ,  Alexios-Leandros Skaltsounis ,  Harris Pratsinis
Affiliations
  • 1. Division of Pharmacognosy, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Greece.
PMID: 12443763 DOI: 10.1016/s0960-894x(02)00823-5
Abstract

The preparation and cytotoxic activity of 4'-azido-3'-bromo-3'-deamino-4'-deoxydaunorubicin is described. The new compound was found to be less active in vitro than adriamycin against L1210 and the sensitive cell lines KB-3-1 and MES-SA, but retained interesting cytotoxicity against the adriamycin resistant subline KB-A1 and the multidrug resistant MES-SA/Dx5 subline.

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