Drug Intermediate
Drug Iintermediate
Drug intermediates are used as raw materials for the production of bulk drugs, or they can refer to a material produced during synthesis of an API that must undergo further molecular change or processing before it becomes an API. Drug intermediates are hygienically formulated using high grade raw materials and they are used in the pharmaceutical and cosmetic industry[1][2].
References:
- [1]. Ma HC, et al. Homochiral Covalent Organic Framework for Catalytic Asymmetric Synthesis of a Drug Intermediate. J Am Chem Soc. 2020 Jul 22;142(29):12574-12578. [Content Brief]
- [2]. Ramachary D B, et al. Development of pharmaceutical drugs, drug intermediates and ingredients by using direct organo‐click reactions[J]. 2008.
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Drug Intermediate Related Products (4595)
Related Products (4595)
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Octakis-(6-bromo-6-deoxy)-γ-cyclodextrin
0 ImagesOctakis-(6-bromo-6-deoxy)-γ-cyclodextrin is a perbrominated γ-cyclodextrin at the primary side. Octakis-(6-bromo-6-deoxy)-γ-cyclodextrin is also a commonly used intermediate in the modification of cyclodextrin.
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Furfuryl acetate
0 ImagesFurfuryl acetate can be used in the synthesis of 5-acetoxymethyl-2-vinylfuran and 5-hydroxymethyl-2-vinylfuran.
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Doxepin Hydrochloride (Standard)
0 ImagesDoxepin Hydrochloride (Standard) is the analytical standard of Doxepin Hydrochloride (HY-B0725). This product is intended for research and analytical applications. Doxepin Hydrochloride is an orally active, blood-brain barrier penetrant tricyclic antidepressant with multiple activities including hypnosis, sedation, analgesia and vasodilation. Doxepin Hydrochloride enhances the expression of PSD-95 and synapsin 1 via the PI3K/AKT/mTOR signaling pathway, and is metabolized to DesmethylDoxepin Hydrochloride in vivo. Doxepin Hydrochloride can be used in research related to various diseases such as depression, anxiety, obesity and atopic dermatitis.
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Valnivudine hydrochloride
0 ImagesSynonyms: FV-100FV-100 is a potent, selective and orally active anti-varicella zoster virus agent. FV-100 is a proagent of CF-1743. FV-100 exhibits very low toxicity in vivo.
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L-2-Aminobutyric acid-d3
0 ImagesCat. No.: HY-W010589SCAS No.: 929202-07-3Synonyms: H-Abu-OH-d3L-2-Aminobutyric acid-d3 is the deuterium labeled L-2-Aminobutyric acid. L-2-Aminobutyric acid is a non-proteinogenic amino acid that exists in human tissues and body fluids. L-2-Aminobutyric acid is formed by the transamination of oxobutyric acid. L-2-Aminobutyric acid can serve as a precursor for anticonvulsant and anti-tuberculosis agents and is a key intermediate in the chemical and pharmaceutical industries.
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RB 101
0 ImagesCat. No.: HY-117702CAS No.: 135949-60-9RB 101 is a blood-brain barrier-crossing prodrug as well as aminopeptidase N and neutral endopeptidase-24.11 inhibitor. RB 101 blocks enkephalin breakdown, elevates extracellular enkephalin levels and activate δ-opioid receptor and dopamine D1 receptor. RB 101 can be used for the research of pain, depressive syndromes, and diabetic neuropathy.
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DSPE-PEG8-OH
0 ImagesCat. No.: HY-185404DSPE-PEG8-OH is a monodisperse lipid-polyethylene glycol conjugate featuring a hydrophobic 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) anchor, an 8-unit discrete (PEG8) spacer, and a terminal hydroxyl (-OH) group. DSPE-PEG8-OH is primarily used in liposome formulation, nanoparticle surface modification, and targeted drug delivery systems.
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P-SCN-Bn-NOTA
0 ImagesCat. No.: HY-178271CAS No.: 147597-66-8P-SCN-Bn-NOTA is a metal chelator and molecular imaging probe precursor that allows radiolabeling with Ga-68. P-SCN-Bn-NOTA can be conjugated to CD70-specific molecules B3, B6, ABDB3 and ABDB6 to form NOTA-labeled derivatives. P-SCN-Bn-NOTA is applicable for preclinical PET/CT imaging of CD70-expressing tumors in NCG mouse PDX models. P-SCN-Bn-NOTA can be used in studies related to CD70-positive tumors.
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Adavosertib acid
0 ImagesCat. No.: HY-177928CAS No.: 2714511-66-5Synonyms: AZD1775 acid; MK-1775 acidAdavosertib (AZD1775; MK-1775) acid (Compound 9) is a derivative of AZD1775 (HY-10993) and can be used for the synthesis of PROTAC.
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β-Glu-PAB(CH2NH2)-Exatecan
0 Imagesβ-Glu-PAB (CH2NH2)-Exatecan is a linker-payload conjugate composed of Exatecan (HY-13631) and β-Glu-PAB (CH2NH2). β-Glu-PAB (CH2NH2)-Exatecan also serves as an intermediate of Mal ((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB-Exatecan (HY-173634). β-Glu-PAB (CH2NH2)-Exatecan is specifically cleaved by β-glucuronidase, which is highly expressed in the tumor microenvironment, to release Exatecan that exerts cytotoxic effects. β-Glu-PAB (CH2NH2)-Exatecan can be used in cancer research.
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Chlorthal-dimethyl (Standard)
0 ImagesSynonyms: Dimethyl tetrachloroterephthalate (Standard)Chlorthal-dimethyl (Standard) is the analytical standard of Chlorthal-dimethyl. This product is intended for research and analytical applications. Chlorthal-dimethyl (Dimethyl tetrachloroterephthalate) is a plant growth regulator. Chlorthal-dimethyl affects cell division and differentiation, interfering with the normal development of vascular tissue. Chlorthal-dimethyl causes localized swelling of tomato hypocotyls and disrupts normal mitosis in germinating millet seedlings.
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5α-Cholestane-d6
0 Images5α-Cholestane-d6 is the deuterium labeled 5α-Cholestane (HY-133970). 5α-Cholestane is a skeleton. 5α-Cholestane can be used in the synthesis of Brassinosteroids. 5α-Cholestane can be used in skeletal muscle research.
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AFP464 free base
0 ImagesCat. No.: HY-16031CAS No.: 468719-52-0Synonyms: NSC710464 free baseAFP464 (NSC710464) free base is a prodrug of Aminoflavone (HY-132974) and an agonist of the aryl hydrocarbon receptor (AhR). AFP464 free base downregulates the expression of α6-integrin (α6-integrin), inhibits breast tumor growth, reduces the population of tumor-initiating cells, disrupts mammosphere structure, induces the formation of mucin lake clusters, triggers DNA damage, and exerts antiproliferative activity. AFP464 free base is rapidly converted to Aminoflavone by nonspecific esterases in plasma and cell culture media. AFP464 free base is applicable to research related to breast cancer.
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G-814 intermediate-1
0 ImagesCat. No.: HY-48306CAS No.: 1430463-95-8G-814 intermediate-1 (compound 9) is an intermediate in the synthesis of G-814. G-814 intermediate-1 can be used for the synthesis of ADCs.
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p-Tolualdehyde-d7
0 Imagesp-Tolualdehyde-d7 is the deuterium labeled p-Tolualdehyde (HY-W012860). p-Tolualdehyde is the active small molecule, that could used as drug intermediate.
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Phenylglyoxylic acid sodium
0 ImagesCat. No.: HY-W010255ACAS No.: 43165-51-1Synonyms: Benzoylformic acid sodiumPhenylglyoxylic acid sodium (Benzoylformic acid sodium) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human. Phenylglyoxylic acid sodium can be used as drug intermediate for synthesis of antineoplastic compounds.
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Previtamin D3
0 ImagesPrevitamin D3 is an orally active, thermolabile steroidal compound that generates vitamin D3, as well as biologically inactive lumisterol and tachysterol. Previtamin D3 is synthesized in the skin of humans and rats via the UV-B-mediated photoconversion of 7-dehydrocholesterol. Previtamin D3 lacks direct anti-rachitic activity, and its in vivo activity relies on the vitamin D3 it produces. Previtamin D3 can be used in studies related to rickets and vitamin D metabolism.
