G-814 intermediate-1

Cat. No.: HY-48306: Data Sheet
SDS
Handling Instructions
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G-814 intermediate-1 (compound 9) is an intermediate in the synthesis of G-814. G-814 intermediate-1 can be used for the synthesis of ADCs.

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G-814 intermediate-1 Chemical Structure

CAS No. : 1430463-95-8

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Description

G-814 intermediate-1 (compound 9) is an intermediate in the synthesis of G-814. G-814 intermediate-1 can be used for the synthesis of ADCs^[1].

Molecular Weight

953.36

Formula

C₅₀H₈₀N₄O₁₀Si₂

CAS No.

1430463-95-8

Appearance

Solid

SMILES

O=C(N1[C@@H](CC(C1)=C)CO[Si](C)(C)C(C)(C)C)C2=C(C=C(C(OC)=C2)OCCCCCOC3=C(C=C(C(N)=C3)C(N4[C@@H](CC(C4)=C)CO[Si](C)(C)C(C)(C)C)=O)OC)NC(OC(C)(C)C)=O

Shipping

Shipping with dry ice.

Storage

-80°C

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (104.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0489 mL	5.2446 mL	10.4892 mL
5 mM	0.2098 mL	1.0489 mL	2.0978 mL
10 mM	0.1049 mL	0.5245 mL	1.0489 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (269 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Stefan G. Koenig, et al. Development of Dual Practical Manufacturing Routes to Cognate
Pyrrolobenzodiazepine-Based Linker-Drugs. Org. Process Res. Dev. 2022, 26, 2155-2175.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0489 mL	5.2446 mL	10.4892 mL	26.2230 mL
	5 mM	0.2098 mL	1.0489 mL	2.0978 mL	5.2446 mL
	10 mM	0.1049 mL	0.5245 mL	1.0489 mL	2.6223 mL
	15 mM	0.0699 mL	0.3496 mL	0.6993 mL	1.7482 mL
	20 mM	0.0524 mL	0.2622 mL	0.5245 mL	1.3112 mL
	25 mM	0.0420 mL	0.2098 mL	0.4196 mL	1.0489 mL
	30 mM	0.0350 mL	0.1748 mL	0.3496 mL	0.8741 mL
	40 mM	0.0262 mL	0.1311 mL	0.2622 mL	0.6556 mL
	50 mM	0.0210 mL	0.1049 mL	0.2098 mL	0.5245 mL
	60 mM	0.0175 mL	0.0874 mL	0.1748 mL	0.4371 mL
	80 mM	0.0131 mL	0.0656 mL	0.1311 mL	0.3278 mL
	100 mM	0.0105 mL	0.0524 mL	0.1049 mL	0.2622 mL