β-Glu-PAB(CH2NH2)-Exatecan
Based on 1 Customer Validation
β-Glu-PAB (CH2NH2)-Exatecan is a linker-payload conjugate composed of Exatecan (HY-13631) and β-Glu-PAB (CH2NH2). β-Glu-PAB (CH2NH2)-Exatecan also serves as an intermediate of Mal ((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB-Exatecan (HY-173634). β-Glu-PAB (CH2NH2)-Exatecan is specifically cleaved by β-glucuronidase, which is highly expressed in the tumor microenvironment, to release Exatecan that exerts cytotoxic effects. β-Glu-PAB (CH2NH2)-Exatecan can be used in cancer research.
For research use only. We do not sell to patients.
- Purity: 99.60%
- CAS No.: 3025108-11-3
- Formula: C39H39FN4O13
- Molecular Weight:790.74
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
Description
IC50 & Target
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Topoisomerase |
In Vitro
Mal ((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB-Exatecan consists of Exatecan (HY-13631), a potent DNA topoisomerase I inhibitor, and the linker Mal ((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB (HY-173635), and can be used to prepare the antibody-drug conjugate (ADC) AZD0516 (HY-173639)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3025108-11-3
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Appearance Solid
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Molecular Weight 790.74
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Formula C39H39FN4O13
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Color Off-white to light yellow
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SMILES
NCC(C=C1COC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=C(C=C1)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : ≥ 100 mg/mL (126.46 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (298 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.2646 mL | 6.3232 mL | 12.6464 mL | 31.6160 mL |
| 5 mM | 0.2529 mL | 1.2646 mL | 2.5293 mL | 6.3232 mL | |
| 10 mM | 0.1265 mL | 0.6323 mL | 1.2646 mL | 3.1616 mL | |
| 15 mM | 0.0843 mL | 0.4215 mL | 0.8431 mL | 2.1077 mL | |
| 20 mM | 0.0632 mL | 0.3162 mL | 0.6323 mL | 1.5808 mL | |
| 25 mM | 0.0506 mL | 0.2529 mL | 0.5059 mL | 1.2646 mL | |
| 30 mM | 0.0422 mL | 0.2108 mL | 0.4215 mL | 1.0539 mL | |
| 40 mM | 0.0316 mL | 0.1581 mL | 0.3162 mL | 0.7904 mL | |
| 50 mM | 0.0253 mL | 0.1265 mL | 0.2529 mL | 0.6323 mL | |
| 60 mM | 0.0211 mL | 0.1054 mL | 0.2108 mL | 0.5269 mL | |
| 80 mM | 0.0158 mL | 0.0790 mL | 0.1581 mL | 0.3952 mL | |
| 100 mM | 0.0126 mL | 0.0632 mL | 0.1265 mL | 0.3162 mL |
β-Glu-PAB(CH2NH2)-Exatecan Related Classifications
HY-173703 Related Classifications
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