5α-Cholestane-d6
Based on 1 Customer Validation
5α-Cholestane-d6 is the deuterium labeled 5α-Cholestane (HY-133970). 5α-Cholestane is a skeleton. 5α-Cholestane can be used in the synthesis of Brassinosteroids. 5α-Cholestane can be used in skeletal muscle research.
For research use only. We do not sell to patients.
- Purity: 99.78%
- CAS No.: 358731-18-7
- Formula: C27H42D6
- Molecular Weight:378.71
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 358731-18-7
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Unlabeled Cas 481-21-0
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Appearance Solid
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Molecular Weight 378.71
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Formula C27H42D6
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Color White to off-white
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SMILES
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@@](C([2H])([2H])C([2H])([2H])C([2H])([2H])C4)([H])CC3)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
Ethanol : ≥ 20 mg/mL (52.81 mM)
DMF : ≥ 1 mg/mL (2.64 mM)
DMSO : ≥ 0.1 mg/mL (0.26 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Esposito D, et al. Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells. J Med Chem. 2011 Jun 23;54(12):4057-66. [Content Brief]
[3]. Schönning C, et al. Faecal contamination of source-separated human urine based on the content of faecal sterols. Water Res. 2002 Apr;36(8):1965-72. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF / Ethanol | 1 mM | 2.6405 mL | 13.2027 mL | 26.4054 mL | 66.0136 mL |
| Ethanol | 5 mM | 0.5281 mL | 2.6405 mL | 5.2811 mL | 13.2027 mL |
| 10 mM | 0.2641 mL | 1.3203 mL | 2.6405 mL | 6.6014 mL | |
| 15 mM | 0.1760 mL | 0.8802 mL | 1.7604 mL | 4.4009 mL | |
| 20 mM | 0.1320 mL | 0.6601 mL | 1.3203 mL | 3.3007 mL | |
| 25 mM | 0.1056 mL | 0.5281 mL | 1.0562 mL | 2.6405 mL | |
| 30 mM | 0.0880 mL | 0.4401 mL | 0.8802 mL | 2.2005 mL | |
| 40 mM | 0.0660 mL | 0.3301 mL | 0.6601 mL | 1.6503 mL | |
| 50 mM | 0.0528 mL | 0.2641 mL | 0.5281 mL | 1.3203 mL |
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