Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome Related Products (1007):

By Effects:	Inhibitors (2) Controls (2) Substrate (1) Modulator (1) Chemicals (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-182095

DSPE-PEG1000-CTP
DSPE-PEG1000-CTP is a PEG compound which composed of DSPE and a Cardiac-targeting peptide CTP (HY-P4094). CTP molecules that specifically recognize cardiac tissue and is primarily used for targeted drug delivery. CTP effectively recognizes and binds to specific receptors on the surface of cardiac cells, thereby achieving precise localization of drug molecules. DSPE-PEG1000-CTP can be used for drug delivery.

HY-W1130452

Lipid C16-C
Lipid C16-C is an ionizable cationic lipid that can be used to prepare lipid nanoparticles (LNPs) for mRNA delivery. Lipid C16-C mediates ApoE-independent macropinocytosis-based mRNA delivery to macrophages, with endosomal acidification enabling endosomal escape and release of mRNA cargo into the cytosol.

HY-177838

Liposomal Silymarin
Liposomal Silymarin is a specialized delivery system that encapsulates silymarin within tiny liposomes. These liposomes act as protective shells, enhancing the absorption and bioavailability of silymarin. Silymarin is a natural flavonoid compound derived

HY-172492

DSPE-PEG5000-ESBP
DSPE-PEG5000-ESBP is a PEG compound which composed of DSPE and a E-selectin-binding peptide (ESBP). As a tumor-targeting peptide, ESBP can specifically recognize and bind to receptors or markers on the surface of tumor cells.

HY-147207

Phospholipid-PEG1000-Biotin
Phospholipid-PEG1000-Biotin is a phospholipid PEG derivative that has a biotin and a phospholipid bridged by a linear PEG linker. Phospholipid-PEG1000-Biotin can interact with avidinylated antibodies. Phospholipid-PEG1000-Biotin can be used to modify liposome and cells surface, and pancreatic islets for cell transplantation.

HY-141420

PtdIns-(3,4,5)-P3(1,2-dihexanoyl) ammonium
PtdIns-(3,4,5)-P3(1,2-dihexanoyl) ammonium (compound 850176) is a vaccine adjuvant that enhances the immune function of vaccines.

HY-172476A

DSPE-PEG3400-YIGSR
DSPE-PEG3400-YIGSR is a PEG compound which composed of DSPE and a biomimetic peptide YIGSR. YIGSR interacts with the 67 kDa laminin binding protein (LBP) and promotes adhesion and spreading of a large number of cell types including endothelial cells, fibroblasts and smooth muscle cells. DSPE-PEG3400-YIGSR can be used for drug delivery.

HY-179745

18:2 TAP chloride
18:2 TAP (chloride) is a cationic lipid .

HY-171951

31hP
31hP is an asymmetric A³ lipid. 31hP can facilitate in vivo luciferase expression. 31hP can be rapidly degraded in the presence of esterase owing to two biocleavable ester bonds. 31hP can be used in the synthesis of lipid nanoparticles (LNPs).

HY-165603

Si5-N14
Si5-N14 is a key component of siloxane-incorporated lipid nanoparticles (SiLNP), possessing pro-vascular repair and anti-tumor activities. In the transgenic GFP mouse model, Si5-N14 can mediate CRISPR-Cas9 editing. In the Lewis lung carcinoma (LLC) tumor-bearing mouse model, Si5-N14 can knock out the expression of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) to exert an anti-tumor effect. In a mouse model of lung injury induced by viral infection, the delivery of Fibroblast Growth Factor-2 (FGF-2) mRNA via Si5-N14 can promote vascular repair, increase blood oxygen levels, and improve lung function. Si5-N14 shows promise for research in the fields of oncology, pneumonia, and cardiovascular diseases.

HY-165975

(2S)-3-Keto sphinganine (d6:0) hydrochloride
(2S)-3-Keto sphinganine (d6:0) ((2S)-3-Keto-C6-dihydrosphingosine) hydrochloride is a lipid compound that can be used for liposome preparation. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble loads can be captured in the internal aqueous space of liposomes, while lipophilic loads can be distributed into the lipid bilayer and become part of the lipid bilayer. Especially for the delivery of antisense oligonucleotides, it can overcome the problems of inefficient cellular uptake and rapid loss in the body.

HY-140736A

DSPE-PEG1000-Biotin
DSPE-PEG1000-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W1049124A

PEG5000-C-DMG
PEG5000-C-DMG is a PEGylated derivative of 1,2-Dimyristoyl-sn-glycerol (HY-128468). PEG5000-C-DMG can be combined with other lipids to form lipid nanoparticles (LNPs) for the delivery of siRNA.

HY-172329

Q1-ALC-0315 iodide
Q1-ALC-0315 iodide is a cationic quaternary ammonium lipid derivative of the ionizable cationic lipid ALC-0315 (HY-138170). Q1-ALC-0315-based LNPs can be used for lung-targeted mRNA delivery, which demonstrates high-performing firefly luciferase protein expression in the lungs.

HY-160569

C14-SPM	Chemical
C14-SPM is a polyamine branched-chain lipidoid that can be used for the delivery of siRNA.

HY-179911

mPEG2000-DLG
mPEG2000-DLG is a PEG-based lipid that can be used to formulate lipid nanoparticles for drug delivery.

HY-177193

DMPA
DMPA (1,2-Dimyristoyl-sn-glycero-3-phosphate; 1,2-Dimyristoyl-PA) is a phospholipid that can be used for preparing liposomes. DMPA, when used as a negatively charged lipid component in fluid liposomes, supports liposome-bacterium fusion. DMPA can be used in the research of drug delivery.

HY-155926

DMPE-PEG750 ammonium
DMPE-PEG750 ammonium (14:0 PEG750 PE ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymeric nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-W779204

rac-3-Hexadecanamido-2-methoxypropan-1-ol phosphocholine hydrate
rac-3-Hexadecanamido-2-methoxypropan-1-ol Phosphocholine Monohydrate is a phospholipid and an inhibitor of Protein kinase C.

HY-164720

DSPE-PEG4000-OH
DSPE-PEG4000-OH is a hydroxy-terminated phospholipid PEG polymer. The hydrophobic tails that allows the encapsulation and aggregation of other hydrophobic drugs, and the hydroxy-terminated can be further reacted. DSPE-PEG4000-OH can prepare liposomes or lipid nanoparticles, which can be used in drug delivery and promoting drug absorption research.

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