Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome Related Products (1007):

By Effects:	Inhibitors (2) Controls (2) Substrate (1) Modulator (1) Chemicals (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-160273

DOPE-PEG5000-Fluor 488
DOPE-PEG5000-Fluor 488 is a PEG lipid, composed of a DOPE phospholipid and a Fluor 488 dye.

HY-125734

DMHAPC-Chol
DMHAPC-Chol, a cationic lipid, contains a biodegradable carbamoyl linker and a hydroxyethyl group in the polar amino head moiety. DMHAPC-Chol can be used in both transfection experiments concerning plasmids or siRNA.

HY-W719862

16:0 PDP PE
16:0 PDP PE belongs to a class of head group modified functionalized lipids. 16:0 PDP PE has been used in preparation of rhodamine high-density lipoprotein nanoparticle (Rh-HDL NP) synthesis.

HY-168381

Lipid A6
Lipid A6 is a biodegradable alkyne lipid that can be used to synthesize lipid-like nanoparticles (LNPs) for delivery of mRNA.

HY-W800848

3,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol]
3,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol] is a SS-cleavable proton-activated lipid-like material (SSPalm). 3,3'-[Dithiobis[2,1-ethanediyl(methylimino)]]bis[1-propanol] can be used for delivery of plasmid DNA.

HY-W327840

N-Methyldioctadecylamine
N-Methyldioctadecylamine (Dioctadecylmethylamine; MDOA) is a surfactant and an ionizable cationic helper lipid that can be used for the preparation of lipid nanoparticles. When used in combination with iPhos 9A1P9 (HY-W590683) in ionizable lipid nanoparticles (iPLNPs), N-Methyldioctadecylamine enables liver-selective mRNA expression. N-Methyldioctadecylamine supports initial in vitro and in vivo mRNA delivery screening for iPhos lipids.

HY-W1130407

CP-LC-1073
CP-LC-1073 is a specific ionizable cationic amino lipid derived from the amino acid homocysteine. CP-LC-1073 can used in lipid nanoparticle (LNP) formulations for efficient in vivo delivery and expression of RNA (mRNA, cRNA, saRNA).

HY-W800796

18:1 Biotinyl PE
18:1 Biotinyl PE is a biotin-functionalized lipid attached to a phosphoethanolamine linked to two oleic acid groups.

HY-140736B

DSPE-PEG5000-Biotin
DSPE-PEG5000-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-W440998

DSPE-alkyne
DSPE-alkyne is a phospholipid. DSPE-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-172014

CP-LC-0743
CP-LC-0743 is an ionizable cationic amino lipid efficient delivery of different kinds of RNA (mRNA, cRNA and saRNA).

HY-W440921

DSPE-PEG5000-Rhodamine
DSPE-PEG5000-Rhodamine is a phospholipid polyPEG with red fluorescent. The polymer can form lipid bilayer and be used to prepare nanoparticles or liposomes for targeted drug delivery. Rhodamine has maximum absorption at 570 nm and emission around 595 nm and can be easily traced using an imaging technique.

HY-W1121519

6,6′-Trehalose dioleate
6,6′-Trehalose dioleate is a glycolipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

HY-145782

Witepsol
Witepsol is a selective lipid-based vehicle for use in drug delivery systems.

HY-138170GL

ALC-0315 (GMP Like)
ALC-0315 (GMP Like) is ALC-0315 (HY-138170) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine.

HY-W440938

Stearic acid-PEG2000-FITC
Stearic acid-PEG2000-FITC is an amphiphatic polyPEG which can self assemble to form micelles in water. The polymer can be used to encapsulate therapeutic agent. FITC is a green dye with peak absorption at 494 nm and maximum emission at 520 nm and can be used for staining biological samples or nanoparticles. FITC can be easily traced by fluorescence microscopy.

HY-130462S2

1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-¹³C₁₆
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-¹³C₁₆ (POPC-¹³C16) is ¹³C labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC), a phospholipid, is a major component of biological membranes. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PC is used for the preparation of liposomes and studying the properties of lipid bilayers.

HY-155927

DMPE-PEG1000 ammonium
DMPE-PEG1000 ammonium (14:0 PEG1000 PE ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

HY-W714524A

1-Palmitoyl-2-oleoyl-sn-glycero-3-PS		99.56%
2-Oleoyl-1-palmitoyl-sn-glycero-3-phospho-L-serine (16:0-18:1 PS (POPS) free acid) is an anionic phospholipid with oleic acid (18:1) and palmitic acid (16:0) tails containing a carboxylic acid (COOH) and amine (NH2) in their head group. 2-Oleoyl-1-palmitoyl-sn-glycero-3-phospho-L-serine has been used in the preparation of lipid-mixing vesicles, liposomes, and artificial membranes.

HY-157657

Cardiolipin (16:1/16:1/16:1/16:1) sodium salt
Cardiolipin (16:1/16:1/16:1/16:1) sodium salt is an anionic phospholipid that promote hydroxyapatite crystallization and supersaturation in a calcium solution.

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