Kidney-targeting peptide

Name: Kidney-targeting peptide
Brand: MedChemExpress
SKU: HY-P11069
Rating: 4.5 (1 reviews)

Cat. No.: HY-P11069 Purity: 99.87%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Kidney-targeting peptide is a kidney-targeting peptide (KTP). Kidney-targeting peptide significantly enhances the renal targeting ability of Isoquercitrin (HY-N1445). Kidney-targeting peptide can be used in diabetic nephropathy research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Kidney-targeting peptide Chemical Structure

CAS No. : 3106628-25-2

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

kidney-targeting peptide (Isoquercitrin: 300 μg/mL; intravenous injection; single administration) significantly enhances the renal targeting of vectors in healthy mice, achieving a renal accumulation level of 20% ID/g while reducing off-target distribution to other major organs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Unstated strain (male, used for in vivo biodistribution studies)^[1]
Dosage:	300 μg/mL isoquercitrin equivalent dose
Administration:	i.v.; single injection
Result:	Achieved significantly higher renal fluorescence signal (drug accumulation) compared to non-KTP-containing control nanocarriers at 6, 12, and 18 hours post-administration. Exhibited significantly lower fluorescence signal in heart, liver, spleen, and lungs compared to non-KTP-containing control nanocarriers at 6, 12, and 18 hours post-administration. Achieved a renal targeting efficiency of 20% ID/g.

Molecular Weight

2180.39

Formula

C₉₀H₁₅₄N₂₄O₃₆S

CAS No.

3106628-25-2

Appearance

Solid

Color

White to off-white

Sequence

Cys-Lys-Lys-Glu-Glu-Glu-Lys-Lys-Glu-Glu-Glu-Lys-Lys-Glu-Glu-Glu-Lys

Sequence Shortening

CKKEEEKKEEEKKEEEK

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (11.47 mM; Need ultrasonic)

DMSO : 25 mg/mL (11.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.4586 mL	2.2932 mL	4.5863 mL
5 mM	0.0917 mL	0.4586 mL	0.9173 mL
10 mM	0.0459 mL	0.2293 mL	0.4586 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (246 KB) RP-HPLC (258 KB) MS (71 KB)

Handling Instructions (2659 KB)

References

[1]. Xuan C, et al. Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization. Adv Sci (Weinh). 2025;12(25):e2414587. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	0.4586 mL	2.2932 mL	4.5863 mL	11.4658 mL
	5 mM	0.0917 mL	0.4586 mL	0.9173 mL	2.2932 mL
	10 mM	0.0459 mL	0.2293 mL	0.4586 mL	1.1466 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.