2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MetAP

MetAP

Methionine Aminopeptidase

Methionine aminopeptidase (MetAP) is an enzyme that plays a crucial role in protein biosynthesis. MetAP is responsible for the removal of the N-terminal methionine residue from nascent polypeptide chains, which is essential for the proper folding, maturation and function of many proteins. MetAP1 and MetAP2 have different subcellular localizations and substrate specificities. MetAP1 is mainly involved in the processing of cytosolic proteins. MetAP2 is of particular interest in cancer research as it is involved in angiogenesis and has been targeted for anti-cancer drug development. Inhibition of MetAP2 can disrupt the growth and proliferation of cancer cells by interfering with the processing of certain proteins involved in angiogenesis[1][2].

MetAP Isoform Specific Products:

MetAP Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-158006
    SDX-7539
    		Inhibitor
    SDX-7539 is a selective inhibitor for Methionine aminopeptidase type 2 (MetAP2). SDX-7539 inhibits proliferarion of HUVECs with an IC50 of 120 μM. SDX-7539 exhibits antitumor activity in NSCLC xenograft athymic nude mice.
    SDX-7539
  • HY-126564
    Ebelactone A
    		Inhibitor 98.28%
    Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC50s of 56, 3, 8 and 7.5 μM, respectively. Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis.
    Ebelactone A
  • HY-182482
    SB-587094
    		Inhibitor
    SB-587094 is a MetAP-2 inhibitor. SB-587094 inhibits cobalt- and manganese-containing hMetAP2. SB-587094 inhibits endothelial cell proliferation. SB-587094 is applicable to cancer-related research.
    SB-587094
  • HY-181643
    YOK24
    		Inhibitor
    YOK24 is an orally active MetAP2 inhibitor and anti-amoebic agent. YOK24 binds covalently to MetAP2 and inhibits its peptidase activity, where MetAP2 is a protein essential for the proliferation of *Entamoeba histolytica*. YOK24 can be used in the research of amoebiasis.
    YOK24
  • HY-182781
    Anticancer agent 313
    		Inhibitor
    Anticancer agent 313 is a MetAP2 inhibitor with an IC50 of 4.11 μM. Anticancer agent 313 activates the transcription factor ATF4 via a non-canonical mTORC1-dependent pathway. Anticancer agent 313 inhibits cancer cell proliferation. Anticancer agent 313 is applicable to the research of breast cancer and pancreatic cancer.
    Anticancer agent 313
  • HY-181644
    NS-181
    		Inhibitor
    NS-181 is an orally active MetAP2 inhibitor and antiamebic agent with oral effectiveness.NS-181 functionally inhibits methionine aminopeptidase 2, a protein critical for Entamoeba histolytica proliferation. NS-181 exerts antiamebic activity against Entamoeba histolytica, leading to resolution of amebic liver abscess. NS-181 can be used for the research of amebiasis.
    NS-181
  • HY-14811A
    Beloranib hemioxalate
    		Inhibitor
    Beloranib (ZGN-440; CKD-732 free base) hemioxalate is a selective, irreversible inhibitor of methionine aminopeptidase MetAP2 that suppresses appetite and increases energy expenditure. Beloranib hemioxalate blocks the enzymatic cleavage of N-terminal methionine from nascent proteins by forming a covalent bond with MetAP2, thereby regulating fatty acid metabolism, adrenergic signaling, and hypothalamic NF-κB expression. Beloranib hemioxalate significantly reduces food intake, body weight, and fat accumulation, while improving glucose tolerance, insulin sensitivity, and lipid metabolism. Beloranib hemioxalate also elevates energy expenditure and fat oxidation levels, without affecting body temperature, spontaneous activity, or the inflammatory cytokine IL-1β. Beloranib hemioxalate can be used in research on obesity and hypothalamic obesity.
    Beloranib hemioxalate
  • HY-148442
    ecMetAP-IN-1
    		Inhibitor 98.12%
    ecMetAP-IN-1 is an inhibitor of E. coli methionine aminopeptidase (ecMetAP) with an IC50 of 2.086 μM. ecMetAP-IN-1 is applicable to research related to bacterial infections caused by E. coli.
    ecMetAP-IN-1
MetAP Isoform Comparison

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