Antibacterial agent 353 

Antibacterial agent 353 is an antibacterial agent with bactericidal activity against multidrug-resistant pathogens including Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Methicillin (HY-121544)-resistant Staphylococcus aureus. Antibacterial agent 353 disrupts bacterial membrane integrity, leading to cell lysis and death. Antibacterial agent 353 demonstrates in vivo antibacterial activity in the Galleria mellonella larval infection model. Antibacterial agent 353 can be used for the research of multidrug-resistant bacterial infections^[1].

Antibacterial agent 353 (Compound 17j) (0.125-8 μg/mL) potently inhibits and kills Pseudomonas aeruginosa ATCC 15442 (MIC = 0.125 μg/mL, MBC = 1 μg/mL), Acinetobacter baumannii ATCC 19606 (MIC = 0.25 μg/mL, MBC = 1 μg/mL), Klebsiella pneumoniae ATCC 13883 (MIC = 0.25 μg/mL, MBC = 1 μg/mL), and methicillin-resistant Staphylococcus aureus ATCC 43300 (MIC = 1 μg/mL, MBC = 8 μg/mL)^[1].
Antibacterial agent 353 (0.25-4 μg/mL; 0-24 h) exhibits concentration- and time-dependent bactericidal activity against Pseudomonas aeruginosa ATCC 15442 and Acinetobacter baumannii ATCC 19606^[1].
Antibacterial agent 353 (0.5-1 μg/mL) disrupts the membrane integrity of Pseudomonas aeruginosa ATCC 15442 in a concentration-dependent manner, causing cell rupture and death^[1].
Antibacterial agent 353 (0-40 μM) exhibits very low in vitro cytotoxicity toward SMMC-7721, MCF7, and Beas-2B mammalian cell lines, with an IC₅₀ >40 μM and a Selectivity Index >112.7^[1].
Antibacterial agent 353 (0.125-8 μg/mL) shows no significant hemolytic toxicity toward rat red blood cells at concentrations up to 8 μg/mL, with hemolytic rates < 5% and a hemolytic Selectivity Index > 64^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 353 (Compound 17j) (0.25-1 mg/kg; single dose; post-infection) exhibits significant in vivo antibacterial activity against Pseudomonas aeruginosa in Galleria mellonella larvae^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

351.48

C₂₀H₃₃NO₄

CCCCCCCCCCCCCNC(/C=C/C1=CC(OC1=O)O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tang SY, et al.. Design, synthesis and antibacterial evaluation of novel unsaturated butenolide-fatty amine hybrids against multidrug-resistant pathogens. Bioorganic & medicinal chemistry letters. 2026 Sep;138:130690.