Antibacterial agent 353

Antibacterial agent 353 (Compound 17j) (0.125-8 μg/mL) potently inhibits and kills Pseudomonas aeruginosa ATCC 15442 (MIC = 0.125 μg/mL, MBC = 1 μg/mL), Acinetobacter baumannii ATCC 19606 (MIC = 0.25 μg/mL, MBC = 1 μg/mL), Klebsiella pneumoniae ATCC 13883 (MIC = 0.25 μg/mL, MBC = 1 μg/mL), and methicillin-resistant Staphylococcus aureus ATCC 43300 (MIC = 1 μg/mL, MBC = 8 μg/mL)^[1].
Antibacterial agent 353 (0.25-4 μg/mL; 0-24 h) exhibits concentration- and time-dependent bactericidal activity against Pseudomonas aeruginosa ATCC 15442 and Acinetobacter baumannii ATCC 19606^[1].
Antibacterial agent 353 (0.5-1 μg/mL) disrupts the membrane integrity of Pseudomonas aeruginosa ATCC 15442 in a concentration-dependent manner, causing cell rupture and death^[1].
Antibacterial agent 353 (0-40 μM) exhibits very low in vitro cytotoxicity toward SMMC-7721, MCF7, and Beas-2B mammalian cell lines, with an IC₅₀ >40 μM and a Selectivity Index >112.7^[1].
Antibacterial agent 353 (0.125-8 μg/mL) shows no significant hemolytic toxicity toward rat red blood cells at concentrations up to 8 μg/mL, with hemolytic rates < 5% and a hemolytic Selectivity Index > 64^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.