LAMP1 Antibody (YA7077)
(Synonyms: LAMP1; Lysosome-associated membrane glycoprotein 1; LAMP-1; Lysosome-associated membrane protein 1; CD107 antigen-like family member A; CD107a)LAMP1 Antibody is a non-conjugated antibody, targeting to CD107a.
-
Formulation:
Supplied in Phosphate-buffered solution.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Product Details
LAMP1 Antibody is a non-conjugated antibody, targeting to CD107a.
-
Clonality Monoclonal
affinity purified.
Non-conjugated
Unmodified
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in Phosphate-buffered solution.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
LAMP1 is a Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins; (Microbial infection) Acts as a receptor for Lassa virus glycoprotein. Also promotes fusion of the virus with host membrane in less acidic endosomes; (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F[1][2][3][4][5][6][7][8][9][10].
-
Subcellular Localization
Lysosome membrane; Single-pass type I membrane protein; Endosome membrane; Single-pass type I membrane protein; Late endosome membrane; Single-pass type I membrane protein; Cell membrane; Single-pass type I membrane protein; Cytolytic granule membrane; Single-pass type I membrane protein
-
Isoforms & Post-Translational Modification
P11279 has 2 isomers: P11279-1: 44882 Da (predicted); P11279-2: 38986 Da (predicted).
O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans;(Microbial infection) The glycosylation of Asn-76 is essential for Lassa virus entry into cells -
Subunit
Interacts with ABCB9; this interaction strongly stabilizes ABCB9 and protects ABCB9 against lysosomal degradation (PubMed:22641697). Interacts with FURIN (PubMed:32295904). Interacts with TMEM175; inhibiting the proton channel activity of TMEM175 (PubMed:37390818)
-
SwissProt ID
-
Synonyms
LAMP1; Lysosome-associated membrane glycoprotein 1; LAMP-1; Lysosome-associated membrane protein 1; CD107 antigen-like family member A; CD107a
Documentation
Powered by Bioz
