FOXP3 Antibody(YA6609)

FOXP3 Antibody(YA6609) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXP3.

Predicted band size: 47 kDa

Q9BZS1

50943 [NCBI]

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Function：Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479, PubMed:24835996, PubMed:30513302, PubMed:32644293). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells (PubMed:23169781). Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG) (PubMed:17377532, PubMed:21458306, PubMed:23947341, PubMed:24354325, PubMed:24722479). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity)

Subcellular Localization：Nucleus,Cytoplasm

Expression：Induction: Down-regulated in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Up-regulated by FOXO3 (PubMed:30513302)

Isoforms & Post-Translational Modification：Q9BZS1 has four isomers: Q9BZS1-1: 47244 Da (predicted); Q9BZS1-2: 43410 Da (predicted); Q9BZS1-3: 49843 Da (predicted); Q9BZS1-4: 44407 Da (predicted).
Polyubiquitinated, leading to its proteasomal degradation in regulatory T-cells (Treg) which is mediated by STUB1 in a HSPA1A/B-dependent manner丨Phosphorylation at Ser-418 regulates its transcriptional repressor activity and consequently, regulatory T-cells (Treg) suppressive function丨Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions (PubMed:17360565, PubMed:24835996)丨Undergoes proteolytic cleavage in activated regulatory T-cells (Treg), and can be cleaved at either the N- or C-terminal site, or at both sites

Subunit：Homodimer (PubMed:21458306, PubMed:25567984)

AIID antibody; DIETER antibody; Forkhead box P3 antibody; Forkhead box protein P3 antibody; FOXP3 antibody; FOXP3_HUMAN antibody; FOXP3delta7 antibody; Immune dysregulation polyendocrinopathy enteropathy X linked antibody; Immunodeficiency polyendocrinopathy enteropathy X linked antibody; IPEX antibody; AIID antibody; DIETER antibody; Forkhead box P3 antibody; Forkhead box protein P3 antibody; FOXP3 antibody; FOXP3_HUMAN antibody; FOXP3delta7 antibody; Immune dysregulation polyendocrinopathy enteropathy X linked antibody; Immunodeficiency polyendocrinopathy enteropathy X linked antibody; IPEX antibody; JM2 antibody; MGC141961 antibody; MGC141963 antibody; OTTHUMP00000025832 antibody; OTTHUMP00000025833 antibody; OTTHUMP00000226737 antibody; PIDX antibody; Scurfin antibody; XPID antibody;