TSC22D3 Antibody (YA8097)
(Synonyms: DIP; DSIPI; GILZ; TSC-22R)TSC22D3 Antibody (YA8097) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TSC22D3.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
ICC/IF
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Reactivity :
Human, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|
| Dilution Ratio | 1:100-250 |
Product Details
TSC22D3 Antibody (YA8097) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TSC22D3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 14.6 kDa
Full length human recombinant protein of human TSC22D3 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TSC22D3 protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities. In vitro, suppresses AP-1 transcription factor complex DNA-binding activities|Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG[1][2][3].
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Subcellular Localization
Cytoplasm,Nucleus
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Expression
Tissue_Specificity: Ubiquitously expressed, including in the fetal brain and liver (PubMed:26752201). Expressed in brain, lung, spleen and skeletal muscle (PubMed:11313722, PubMed:12393603). Lower levels detected in heart and kidney (PubMed:11313722, PubMed:12393603). Not detected in the pancreas (PubMed:11313722). In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage (PubMed:12393603). Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes (PubMed:11313722). Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells (PubMed:12393603)
Induction: Induced in T-lymphocytes by IL2 deprivation -
Isoforms & Post-Translational Modification
Q99576 has three isomers: Q99576-1: 14810 Da (predicted); Q99576-3: 22213 Da (predicted); Q99576-5: 8673 Da (predicted).
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Subunit
Can form homodimers, however it is likely to function as a monomer (By similarity)
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SwissProt ID
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Synonyms
DIP; DSIPI; GILZ; TSC-22R
Documentation
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