Acamprosate calcium
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Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction.
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- Reinheit: 99.91%
- CAS. Nr.: 77337-73-6
- Formel: C5H10NO4S.1/2Ca
- Molecular Weight:200.24
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
Acamprosate calcium (200 mg/kg, sc, twice a day for 3 days) ameliorates alcohol-induced cognitive deficits, exhibits anti-relapse effect in mouse models[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse tail suspension test model[4].
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Dosage:100-400 mg/kg
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Administration:ip, single dose
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Result:Decreased the immobility time in the tail suspension test, decreased the locomotor activity of mice.
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Animal Model:Alcohol-induced cognitive deficits in mouse models[6]
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Dosage:200 mg/kg
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Administration:sc, twice a day for 3 days
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Result:Improved the decrease in attention shifting and object recognition.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 77337-73-6
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Appearance Solid
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Molecular Weight 200.24
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Formel C5H10NO4S.1/2Ca
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Color White to off-white
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SMILES
CC(NCCCS([O-])(=O)=O)=O.[0.5Ca2+]
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Synonyms
Calcium N-acetylhomotaurinate
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
H2O : 100 mg/mL (499.40 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (292 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Preuss UW. Commentary on the study: impact of depressive symptoms on future alcohol use in patients with co-occurring bipolar disorder and alcohol dependence: a prospective analysis in an 8-week randomized controlled trial of acamprosate (Prisciandaro et al.). Alcohol Clin Exp Res. 2012 Jun;36(6):967-9. doi: 10.1111/j.1530-0277.2012.01827.x. [Content Brief]
[2]. Witkiewitz K, Saville K, Hamreus K. Acamprosate for treatment of alcohol dependence: mechanisms, efficacy, and clinical utility. Ther Clin Risk Manag. 2012;8:45-53. [Content Brief]
[3]. Gahr M, et al. Relapse prevention in alcohol dependence: acamprosate and naltrexone as a combined pharmacological strategy.Nervenarzt. 2012 Aug 15. [Content Brief]
[4]. Palucha-Poniewiera A, Pilc A. Involvement of mGlu5 and NMDA receptors in the antidepressant-like effect of acamprosate in the tail suspension test. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):102-6. [Content Brief]
[5]. Hinton DJ, et al. Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1. Neuropharmacology. 2012 Jun;62(8):2480-8. [Content Brief]
[6]. Pradhan G, et al., Calcium chloride mimics the effects of acamprosate on cognitive deficits in chronic alcohol-exposed mice. Psychopharmacology (Berl). 2018 Jul;235(7):2027-2040. [Content Brief]
[7]. Allgaier C, et al., Acamprosate inhibits Ca2+ influx mediated by NMDA receptors and voltage-sensitive Ca2+ channels in cultured rat mesencephalic neurones. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):440-3. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.9940 mL | 24.9700 mL | 49.9401 mL | 124.8502 mL |
| 5 mM | 0.9988 mL | 4.9940 mL | 9.9880 mL | 24.9700 mL | |
| 10 mM | 0.4994 mL | 2.4970 mL | 4.9940 mL | 12.4850 mL | |
| 15 mM | 0.3329 mL | 1.6647 mL | 3.3293 mL | 8.3233 mL | |
| 20 mM | 0.2497 mL | 1.2485 mL | 2.4970 mL | 6.2425 mL | |
| 25 mM | 0.1998 mL | 0.9988 mL | 1.9976 mL | 4.9940 mL | |
| 30 mM | 0.1665 mL | 0.8323 mL | 1.6647 mL | 4.1617 mL | |
| 40 mM | 0.1249 mL | 0.6243 mL | 1.2485 mL | 3.1213 mL | |
| 50 mM | 0.0999 mL | 0.4994 mL | 0.9988 mL | 2.4970 mL | |
| 60 mM | 0.0832 mL | 0.4162 mL | 0.8323 mL | 2.0808 mL | |
| 80 mM | 0.0624 mL | 0.3121 mL | 0.6243 mL | 1.5606 mL | |
| 100 mM | 0.0499 mL | 0.2497 mL | 0.4994 mL | 1.2485 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Acamprosate calcium Related Classifications
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