Art. -Nr.: HY-N0560

Oroxylin A

(Synonyms: Baicalein 6-methyl ether; 6-Methoxybaicalein)

20 Cited Publications

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Based on 20 publication(s) in Google Scholar

Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis.

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Reinheit: 99.40%
CAS. Nr.: 480-11-5
Formel: C₁₆H₁₂O₅
Molecular Weight:284.26

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Oroxylin A Chemical Structure

CAS. Nr.: 480-11-5

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Publications (20)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	33.9 μM Compound: 1, Oroxylin A	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 22196122]
HepG2	IC₅₀	22.7 μM Compound: 1, Oroxylin A	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 22196122]
HUVEC	IC₅₀	61 μM Compound: 5	Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA	[PMID: 9214730]
KB	IC₅₀	16.1 μM Compound: O, oroxylin-A	Cytotoxicity against multi-drug resistant human KB cells overexpressing mdr1 after 3 days Cytotoxicity against multi-drug resistant human KB cells overexpressing mdr1 after 3 days	[PMID: 18722769]
KB	IC₅₀	31.1 μM Compound: O, oroxylin-A	Cytotoxicity against human KB cells after 3 days Cytotoxicity against human KB cells after 3 days	[PMID: 18722769]
MV4-11	GI₅₀	5.59 μM Compound: 14, Oroxylin	Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay	[PMID: 23411073]
RAW264.7	IC₅₀	16.73 μM Compound: 1, oroxylin A	Cytotoxicity against mouse RAW264.7 cells Cytotoxicity against mouse RAW264.7 cells	[PMID: 22101131]
RAW264.7	IC₅₀	48.9 μM Compound: 6	Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in NO production Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in NO production	[PMID: 37778427]
RS4-11	GI₅₀	40 μM Compound: 14, Oroxylin	Cytotoxicity against human RS4:11 cells harboring wild type FLT3 after 72 hrs by tetrazolium based Ez CyTox cell viability assay Cytotoxicity against human RS4:11 cells harboring wild type FLT3 after 72 hrs by tetrazolium based Ez CyTox cell viability assay	[PMID: 23411073]
SW1353	IC₅₀	>50 μM Compound: 5	Antiinflammatory activity in PMA-stimulated human SW1353 cells assessed as inhibition of NF-kappaB activation Antiinflammatory activity in PMA-stimulated human SW1353 cells assessed as inhibition of NF-kappaB activation	[PMID: 19555121]

In Vitro

Oroxylin A (20 μM; 24 h) inhibits the growth, proliferation, and migration of MDA-MB-231 cells. Oroxylin A also inhibits the invasion of MDA-MB-231 and inhibits its epithelial-to-mesenchymal transition (EMT) process^[4].
Oroxylin A (20 μM; 24 h) also inhibits the expression of pro-inflammatory cytokines and inhibits the NF-κB signaling pathway^[4].
The anti-inflammatory effect of Oroxylin A is abolished by TNF-α^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 480-11-5
Appearance Solid
Molecular Weight 284.26
Formel C₁₆H₁₂O₅
Color Light yellow to yellow
SMILES

O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=C(OC)C(O)=C13
Synonyms

Baicalein 6-methyl ether; 6-Methoxybaicalein
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Polyphenols
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (20)

All WBIn Vivo ImagingIFRT-PCRIn Vivo Efficacy Study

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Journal Impact Factor

J Adv Res

FUNDC1 Interacts with GPx4 to Govern Hepatic Ferroptosis and Fibrotic Injury through a Mitophagy-Dependent Manner. [Abstract]

2024 Jan:55:45-60. PMID: 36828120

Oroxylin A purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Jan:55:45-60. [Abstract]

Oroxylin A (OA, 150 μM; 48 h) inhibited mitophagy in CCl₄-treated E47 cells with FUNDC1-OE, as evidenced by downregulation of Parkin and BNIP3 as well as upregulation of TIM23, with subtle changes in FUNDC1.

Oroxylin A purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Jan:55:45-60. [Abstract]

Effect of Oroxylin A (OA) on cell mitophagy and ferroptosis in CCl₄-treated E47 cells with FUNDC1 overexpression. E47 cells were transfected with scrambled or FUNDC1 plasmid for 48 hrs and were then treated DMSO or OA (150 μM; 48 h) prior to exposure to CCl₄ for 12 hrs. Representative images of C11-BODIPY staining.
Acta Pharm Sin B

Chrysin serves as a novel inhibitor of DGK α/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC). [Abstract]

2021 Jan;11(1):143-155. PMID: 33532186
Mater Today Bio

Biocompatible injectable glycyrrhizic acid-based growth factor hydrogel for synergistic endometrial regeneration. [Abstract]

2025 Nov 4:35:102521. PMID: 41281649
Phytother Res

Oroxylin A alleviates myocardial ischemia-reperfusion injury by quelling ferroptosis via activating the DUSP10/MAPK-Nrf2 pathway. [Abstract]

2024 Nov;38(11):5290-5308. PMID: 39225191
Ecotoxicol Environ Saf

Roxithromycin exposure induces motoneuron malformation and behavioral deficits of zebrafish by interfering with the differentiation of motor neuron progenitor cells. [Abstract]

2024 May:276:116327. PMID: 38626605

Oroxylin A purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 May:276:116327. [Abstract]

Oroxylin A (OA, 1 μg/mL; 46 h) an ngn1 agonist, was used to verify the role of ngn1 in this process to determine whether ROX mediates motor nerve development by inhibiting ngn1. In the presence of OA, ROX-induced motor nerve damage was rescued in transgenic zebrafish Tg(hb9:eGFP).

Oroxylin A purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 May:276:116327. [Abstract]

Oroxylin A (OA, 1 μg/mL; 46 h) treatment restored the downregulated expression of the ngn1 gene caused by ROX exposure in Tg(hb9:eGFP) zebrafish by activating ngn1.

Oroxylin A purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 May:276:116327. [Abstract]

Oroxylin A (OA, 1 μg/mL; 46 h) partially rescued the locomotor behavioral deficits associated with ROX exposure in Tg(hb9:eGFP) zebrafish by activating ngn1.
Biochem Pharmacol

Oroxylin A attenuates sepsis-associated coagulopathy by targeting the ALOX12-lipid peroxidation. [Abstract]

2026 Jun:248:117862. PMID: 41794265
Biochem Pharmacol

Targeting the DYNLL2-PAK1 axis inhibits caspase-11-dependent pyroptosis to alleviate sepsis. [Abstract]

2026 Feb:244:117614. PMID: 41360226
Biomolecules

Oroxylin A Directly Targets SRC to Inhibit the PI3K/AKT Signaling Axis in Pancreatic Cancer: An Integrated Bioinformatics and Experimental Study. [Abstract]

2026 May 5;16(5):685. PMID: 42194035
Int Immunopharmacol

Oroxylin A suppress LL-37 generated rosacea-like skin inflammation through the modulation of SIRT3-SOD2-NF-κB signaling pathway. [Abstract]

2024 Mar 10:129:111636. PMID: 38364746
Front Pharmacol

Oroxylin A ameliorates AKI-to-CKD transition through maintaining PPARα-BNIP3 signaling-mediated mitochondrial homeostasis. [Abstract]

2022 Aug 23;13:935937. PMID: 36081929
Sci Rep

RANBP3 promotes mitophagy through the CCAR2/SIRT1 pathway to alleviate pyroptosis in macrophages in TBTB. [Abstract]

2026 Jun 11. PMID: 42277087
Sci Rep

Oroxylin A suppressed colorectal cancer metastasis by inhibiting the activation of the TGF-β/SMAD signal pathway. [Abstract]

2024 Oct 15;14(1):24091. PMID: 39406881
Cancers

Long-Term Exposure to Oroxylin A Inhibits Metastasis by Suppressing CCL2 in Oral Squamous Cell Carcinoma Cells. [Abstract]

2019 Mar 12;11(3):353. PMID: 30871117
Fish Shellfish Immunol

Aeromonas hydrophila induces mitophagy for intracellular survival through its secreted effectors in the splenic macrophages of grass carp (Ctenopharyngodon idella). [Abstract]

2026 Jun:173:111248. PMID: 41786106
Biochim Biophys Acta Mol Cell Biol Lipids

Oroxylin A ameliorates non-alcoholic fatty liver disease by modulating oxidative stress and ferroptosis through the Nrf2 pathway. [Abstract]

2025 May 12:159628. PMID: 40368273
Exp Eye Res

Oroxylin A alleviates pyroptosis and apoptosis in human corneal epithelial cells under hyperosmotic stress by activating the SIRT3-SOD2/HIF-1α pathway. [Abstract]

2025 Jun:255:110345. PMID: 40096905
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Biol Pharm Bull

Oroxylin A Exerts Its Antitumor Effects in Human Gallbladder Cancer via Inhibition of the PTEN/PI3K/AKT Signaling Pathway. [Abstract]

2020;43(10):1511-1518. PMID: 32999161
SSRN

2025 Jul 10.
bioRxiv

2024 Mar 17.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 62.5 mg/mL (219.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5179 mL

17.5895 mL

35.1791 mL

5 mM

0.7036 mL

3.5179 mL

7.0358 mL

10 mM

0.3518 mL

1.7590 mL

3.5179 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhao K, et al. Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. J Hematol Oncol. 2015 Apr 23;8:41. http://www.ncbi.nlm.nih.gov/pubmed/25902914 [Content Brief]

[2]. Dai Q, et al. Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. Mol Carcinog. 2015 Aug 10. [Content Brief]

[3]. Wei L, et al. Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. Cell Death Dis. 2015 Apr 9 [Content Brief]

[4]. Sun X, et al. Oroxylin A Suppresses the Cell Proliferation, Migration, and EMT via NF-κB Signaling Pathway in Human Breast Cancer Cells. Biomed Res Int. 2019 Jun 23;2019:9241769. [Content Brief]

[5]. Yang X, et al. Oroxylin A inhibits colitis-associated carcinogenesis through modulating the IL-6/STAT3 signaling pathway. Inflamm Bowel Dis. 2013 Aug;19(9):1990-2000. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.5179 mL	17.5895 mL	35.1791 mL	87.9477 mL
	5 mM	0.7036 mL	3.5179 mL	7.0358 mL	17.5895 mL
	10 mM	0.3518 mL	1.7590 mL	3.5179 mL	8.7948 mL
	15 mM	0.2345 mL	1.1726 mL	2.3453 mL	5.8632 mL
	20 mM	0.1759 mL	0.8795 mL	1.7590 mL	4.3974 mL
	25 mM	0.1407 mL	0.7036 mL	1.4072 mL	3.5179 mL
	30 mM	0.1173 mL	0.5863 mL	1.1726 mL	2.9316 mL
	40 mM	0.0879 mL	0.4397 mL	0.8795 mL	2.1987 mL
	50 mM	0.0704 mL	0.3518 mL	0.7036 mL	1.7590 mL
	60 mM	0.0586 mL	0.2932 mL	0.5863 mL	1.4658 mL
	80 mM	0.0440 mL	0.2199 mL	0.4397 mL	1.0993 mL
	100 mM	0.0352 mL	0.1759 mL	0.3518 mL	0.8795 mL

Keywords

Oroxylin A

20 Cited Publications

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Oroxylin A

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Publications Citing Use of MedChemExpress (MCE) Oroxylin A

Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (20)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Oroxylin A Related Classifications

HY-N0560 Related Classifications