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Art. -Nr.: HY-183108

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Anticancer agent 315

Anticancer agent 315 is an antitumor agent. Anticancer agent 315 binds to the active pocket of thymidylate synthase via forming strong hydrogen bonds with Lys487 and Ala498, stabilizing the arrangement of the ligand within the pocket. Anticancer agent 315 inhibits the proliferation of tumor cells. Anticancer agent 315 can be used for the research of liver cancer and breast cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₃H₁₇N₁₁O₃S
Molecular Weight:527.52

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 315 Chemical Structure

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Anticancer agent 315 (compound 23) potently inhibits the viability of HepG2 and MCF-7 cancer cells, while exhibiting low toxicity toward WI-38 and VERO normal cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HepG2 and MCF-7 cancer cells, WI-38 and VERO normal cells
Concentration:

/
Incubation Time:

/
Result:

Had IC₅₀ values of 15.9 µM and 18.0 µM for HepG2 and MCF-7 cancer cells.
Had IC₅₀ values of 40.2 µM and 45.7 µM for WI-38 and VERO normal cells.

Chemical Information

Molecular Weight 527.52
Formel C₂₃H₁₇N₁₁O₃S
SMILES

O=C(C1=C(N/N=C(C#N)/C#N)NN=C1NC2=CC=CC=C2)NC3=CC=C(S(=O)(NC4=NC=CC=N4)=O)C=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Bayoumy NM, et al. Design, synthesis, molecular docking and cytotoxic evaluation of novel pyrimidine-based sulfonamide derivatives as potent anticancer agents: SAR insights and biological profiling. Sci Rep. 2026;16(1):9820. Published 2026 Mar 24. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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