COMP - cartilage oligomeric matrix protein Gene
Also Known as MED; CTS2; EDM1; EPD1; TSP5; PSACH; THBS5
Species: Homo sapiens
About COMP
This gene has 4 transcripts (splice variants), 198 orthologues, 5 paralogues and is associated with 6 phenotypes. Biased expression in gall bladder (RPKM 9.2), urinary bladder (RPKM 5.7) and 11 other tissues.
Summary
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to Other ECM proteins such as Collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and Other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016]
COMP Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_000095.3 | NP_000086.2 | cartilage oligomeric matrix protein precursor |
COMP Protein Structure
COMP: Cartilage oligomeric matrix protein (29 - 73)
EGF_CA: Calcium-binding EGF domain (127 - 161)
EGF_CA: Calcium-binding EGF domain (180 - 221)
TSP_3: Thrombospondin type 3 repeat (301 - 336)
TSP_3: Thrombospondin type 3 repeat (360 - 395)
TSP_3: Thrombospondin type 3 repeat (395 - 418)
TSP_3: Thrombospondin type 3 repeat (420 - 456)
TSP_3: Thrombospondin type 3 repeat (457 - 492)
TSP_3: Thrombospondin type 3 repeat (493 - 527)
TSP_C: Thrombospondin C-terminal region (546 - 746)
- 0
- 200
- 400
- 600
- 757 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cartilage oligomeric matrix protein |
|
COMP Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
COMP | P49747 | NUFIP2 | Homo sapiens | Q7Z417 | 32296183 | |
|
Intra
|
COMP | P49747 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
COMP | P49747 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
COMP | P49747 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
COMP | P49747 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
COMP | P49747 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
COMP | P49747 | OTX1 | Homo sapiens | P32242 | 25416956 | |
|
Intra
|
COMP | P49747 | OTX1 | Homo sapiens | P32242 | 25416956 | |
|
Intra
|
COMP | P49747 | OTX1 | Homo sapiens | P32242 | 32296183 | |
|
Intra
|
COMP | P49747 | OTX1 | Homo sapiens | P32242 | 32296183 | |
|
Intra
|
COMP | P49747 | SGTB | Homo sapiens | Q96EQ0 | 32296183 | |
|
Intra
|
COMP | P49747 | ADAMTS12 | Homo sapiens | P58397 | 16611630 | |
|
Cross
|
COMP | P49747 | ACAN | Bos taurus | P13608 | 17588949 |
Recombinant COMP Proteins
| Art. -Nr. | Produktname | Accession | Reinheit |
|---|---|---|---|
| HY-P72945 | COMP Protein, Human (HEK293, His) | P49747-1 (Q21-A757) | ≥ 90%, as determined by reducing SDS-PAGE. |
COMP Antibodies
| Art. -Nr. | Produktname | Anwendung | Reactivity |
|---|---|---|---|
| HY-P811231 | Thrombospondin-5 Antibody | WB, ICC/IF | Human, Mouse, Rat |
| HY-P811547 | Thrombospondin-5 Antibody (YA10096) | WB, IHC-P | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Pseudoachondroplasia |
|
|
| Epiphyseal Dysplasia, Multiple, 1 |
|
|
| Carpal Tunnel Syndrome 2 |
|
|
| Multiple Epiphyseal Dysplasia |
|
|
| Relapsing Polychondritis |
|
|
| Carpal Tunnel Syndrome |
|
|
| Osteoarthritis |
|
|
| Synovitis |
|
|
| Diastrophic Dysplasia |
|
|
| Osteochondrodysplasia |
|
|
| Spondyloepiphyseal Dysplasia Congenita |
|
|
| Arthropathy |
|
|
| Osteochondritis Dissecans |
|
|
| Arthritis |
|
|
| Rheumatoid Arthritis |
|
|
| Psoriatic Arthritis |
|
|
| Thanatophoric Dysplasia, Type I |
|
|
| Spondyloepimetaphyseal Dysplasia, Strudwick Type |
|
|
| Brachydactyly |
|
|
| Reactive Arthritis |
|
|
| Bone Chondrosarcoma |
|
|
| Epiphyseal Dysplasia, Multiple, 5 |
|
|
| Platyspondylic Lethal Skeletal Dysplasia, Torrance Type |
|
|
| Cartilage Disease |
|
|
| Achondroplasia |
|
|
| Chondromalacia |
|
|
| Achondrogenesis, Type Ii |
|
|
| Tendinitis |
|
|
| Epiphyseal Dysplasia, Multiple, 4 |
|
|
| Patella, Chondromalacia Of |
|
|
| Bone Development Disease |
|
|
| Hypochondrogenesis |
|
|
| Bone Disease |
|
|
| Osteochondrosis |
|
|
| Isolated Growth Hormone Deficiency, Type Ia |
|
|
| Kniest Dysplasia |
|
|
| Achondrogenesis |
|
|
| Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly |
|
|
| Spondyloepiphyseal Dysplasia With Congenital Joint Dislocations |
|
|
| Scoliosis |
|
|
| Bone Inflammation Disease |
|
|
| Systemic Lupus Erythematosus |
|
|
| Limited Scleroderma |
|
|
| Brittle Bone Disorder |
|
|
| Myopathy |
|
|
| Connective Tissue Disease |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | COMP | VGNC | VGNC:27590 |
| Macaca mulatta | COMP | VGNC | VGNC:71310 |
| Canis familiaris | COMP | VGNC | VGNC:39500 |
| Rattus norvegicus | COMP | RGD | RGD:2378 |
| Mus musculus | COMP | MGD | MGI:88469 |
| Felis catus | COMP | VGNC | VGNC:61078 |
| Others | COMP | NCBI |