GGFG-PAB-MMAE
Based on 1 Customer Validation
GGFG-PAB-MMAE (Comp 58054-1) is a drug-linker conjugate for ADC. GGFG-PAB-MMAE contains the ADC linker (GGFG-PAB) and a potent tubulin polymerization inhibitor MMAE (HY-15162).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.33%
- CAS. Nr.: 3049886-19-0
- Formel: C62H92N10O13
- Molecular Weight:1185.45
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Alle Drug-Linker Conjugates for ADC Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Auristatin |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3049886-19-0
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Appearance Solid
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Molecular Weight 1185.45
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Formel C62H92N10O13
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Color White to light yellow
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SMILES
O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC(CNC([C@@H](NC(CNC(CN)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)OC)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (84.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8436 mL | 4.2178 mL | 8.4356 mL | 21.0890 mL |
| 5 mM | 0.1687 mL | 0.8436 mL | 1.6871 mL | 4.2178 mL | |
| 10 mM | 0.0844 mL | 0.4218 mL | 0.8436 mL | 2.1089 mL | |
| 15 mM | 0.0562 mL | 0.2812 mL | 0.5624 mL | 1.4059 mL | |
| 20 mM | 0.0422 mL | 0.2109 mL | 0.4218 mL | 1.0545 mL | |
| 25 mM | 0.0337 mL | 0.1687 mL | 0.3374 mL | 0.8436 mL | |
| 30 mM | 0.0281 mL | 0.1406 mL | 0.2812 mL | 0.7030 mL | |
| 40 mM | 0.0211 mL | 0.1054 mL | 0.2109 mL | 0.5272 mL | |
| 50 mM | 0.0169 mL | 0.0844 mL | 0.1687 mL | 0.4218 mL | |
| 60 mM | 0.0141 mL | 0.0703 mL | 0.1406 mL | 0.3515 mL | |
| 80 mM | 0.0105 mL | 0.0527 mL | 0.1054 mL | 0.2636 mL |
GGFG-PAB-MMAE Related Classifications
HY-164788 Related Classifications
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