2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Microtubule/Tubulin
  4. GGFG-PAB-MMAE

GGFG-PAB-MMAE (Comp 58054-1) is a drug-linker conjugate for ADC. GGFG-PAB-MMAE contains the ADC linker (GGFG-PAB) and a potent tubulin polymerization inhibitor MMAE (HY-15162).

For research use only. We do not sell to patients.

GGFG-PAB-MMAE Chemical Structure

GGFG-PAB-MMAE Chemical Structure

CAS No. : 3049886-19-0

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Based on 1 publication(s) in Google Scholar

GGFG-PAB-MMAE Related Antibodies

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View All Drug-Linker Conjugates for ADC Isoform Specific Products:

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Description

GGFG-PAB-MMAE (Comp 58054-1) is a drug-linker conjugate for ADC. GGFG-PAB-MMAE contains the ADC linker (GGFG-PAB) and a potent tubulin polymerization inhibitor MMAE (HY-15162)[1].

IC50 & Target[1]

Auristatin

 

Molecular Weight

1185.45

Formula

C62H92N10O13
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC(CNC([C@@H](NC(CNC(CN)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (101.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8436 mL 4.2178 mL 8.4356 mL
5 mM 0.1687 mL 0.8436 mL 1.6871 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8436 mL 4.2178 mL 8.4356 mL 21.0890 mL
5 mM 0.1687 mL 0.8436 mL 1.6871 mL 4.2178 mL
10 mM 0.0844 mL 0.4218 mL 0.8436 mL 2.1089 mL
15 mM 0.0562 mL 0.2812 mL 0.5624 mL 1.4059 mL
20 mM 0.0422 mL 0.2109 mL 0.4218 mL 1.0545 mL
25 mM 0.0337 mL 0.1687 mL 0.3374 mL 0.8436 mL
30 mM 0.0281 mL 0.1406 mL 0.2812 mL 0.7030 mL
40 mM 0.0211 mL 0.1054 mL 0.2109 mL 0.5272 mL
50 mM 0.0169 mL 0.0844 mL 0.1687 mL 0.4218 mL
60 mM 0.0141 mL 0.0703 mL 0.1406 mL 0.3515 mL
80 mM 0.0105 mL 0.0527 mL 0.1054 mL 0.2636 mL
100 mM 0.0084 mL 0.0422 mL 0.0844 mL 0.2109 mL
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GGFG-PAB-MMAE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GGFG-PAB-MMAE3049886-19-0Drug-Linker Conjugates for ADCMicrotubule/Tubulindrug-linker conjugate for ADCtubulin polymerizationInhibitorinhibitorinhibit

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